3-Dimensional magnetic resonance imaging of the freely moving human eye.

Details

Serval ID
serval:BIB_A712021E806E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
3-Dimensional magnetic resonance imaging of the freely moving human eye.
Journal
Progress in neurobiology
Author(s)
Franceschiello B., Di Sopra L., Minier A., Ionta S., Zeugin D., Notter M.P., Bastiaansen JAM, Jorge J., Yerly J., Stuber M., Murray M.M.
ISSN
1873-5118 (Electronic)
ISSN-L
0301-0082
Publication state
Published
Issued date
11/2020
Peer-reviewed
Oui
Volume
194
Pages
101885
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Eye motion is a major confound for magnetic resonance imaging (MRI) in neuroscience or ophthalmology. Currently, solutions toward eye stabilisation include participants fixating or administration of paralytics/anaesthetics. We developed a novel MRI protocol for acquiring 3-dimensional images while the eye freely moves. Eye motion serves as the basis for image reconstruction, rather than an impediment. We fully reconstruct videos of the moving eye and head. We quantitatively validate data quality with millimetre resolution in two ways for individual participants. First, eye position based on reconstructed images correlated with simultaneous eye-tracking. Second, the reconstructed images preserve anatomical properties; the eye's axial length measured from MRI images matched that obtained with ocular biometry. The technique operates on a standard clinical setup, without necessitating specialized hardware, facilitating wide deployment. In clinical practice, we anticipate that this may help reduce burdens on both patients and infrastructure, by integrating multiple varieties of assessments into a single comprehensive session. More generally, our protocol is a harbinger for removing the necessity of fixation, thereby opening new opportunities for ethologically-valid, naturalistic paradigms, the inclusion of populations typically unable to stably fixate, and increased translational research such as in awake animals whose eye movements constitute an accessible behavioural readout.
Keywords
Adult, Eye Movements/physiology, Eye-Tracking Technology/instrumentation, Eye-Tracking Technology/standards, Feasibility Studies, Female, Functional Neuroimaging/methods, Functional Neuroimaging/standards, Humans, Imaging, Three-Dimensional/methods, Imaging, Three-Dimensional/standards, Magnetic Resonance Imaging/methods, Magnetic Resonance Imaging/standards, Male, Reproducibility of Results, Compressed sensing, Eye, Magnetic resonance imaging (MRI), Motion, Vision
Pubmed
Web of science
Create date
14/09/2021 13:49
Last modification date
05/10/2021 6:40
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