PET with 18fluorodeoxyglucose and hexamethylpropylene amine oxime SPECT in late whiplash syndrome.

Details

Serval ID
serval:BIB_A6F6E1E85707
Type
Article: article from journal or magazin.
Collection
Publications
Title
PET with 18fluorodeoxyglucose and hexamethylpropylene amine oxime SPECT in late whiplash syndrome.
Journal
Neurology
Author(s)
Bicik I., Radanov B.P., Schäfer N., Dvorak J., Blum B., Weber B., Burger C., von Schulthess G.K., Buck A.
ISSN
0028-3878 (Print)
ISSN-L
0028-3878
Publication state
Published
Issued date
08/1998
Peer-reviewed
Oui
Volume
51
Number
2
Pages
345-350
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Many patients have cognitive abnormalities and psychological problems after whiplash injury to the cervical spine. To our knowledge, neuroradiologic imaging has not depicted brain damage that explains the symptoms. Parietotemporo-occipital perfusion deficits on hexamethylpropylene amine oxime (HMPAO) SPECT studies have been described among patients who have sustained whiplash injury.
We examined 13 patients with typical late whiplash syndrome (study group) using HMPAO SPECT, 18fluorodeoxyglucose (FDG) PET, and MRI of the brain and compared the findings with those for 16 control subjects who underwent FDG PET.
In the study group, statistical parametric mapping revealed significantly decreased FDG uptake in the frontopolar and lateral temporal cortex and in the putamen. The frontopolar hypometabolism correlated significantly with scores of the Beck Depression Inventory. However, in individual cases, reliability in the depiction of hypometabolic areas was relatively low. No alterations were found in the parietotemporo-occipital area. In these areas, decreased uptake of HMPAO and FDG correlated with cortical mass.
FDG PET did not allow reliable diagnosis of metabolic disturbances for individual patients. Therefore, we do not recommend FDG PET or HMPAO SPECT as a diagnostic tool in routine examinations of patients with late whiplash syndrome.
Keywords
Adult, Case-Control Studies, Female, Fluorodeoxyglucose F18, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Oximes, Radiopharmaceuticals, Tomography, Emission-Computed/methods, Tomography, Emission-Computed, Single-Photon/methods, Whiplash Injuries/diagnostic imaging
Pubmed
Web of science
Create date
07/12/2017 13:27
Last modification date
21/08/2019 6:36
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