Plasma Hydrogen Sulfide Is Positively Associated With Post-operative Survival in Patients Undergoing Surgical Revascularization.

Details

Serval ID
serval:BIB_A6E0E1F9414C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plasma Hydrogen Sulfide Is Positively Associated With Post-operative Survival in Patients Undergoing Surgical Revascularization.
Journal
Frontiers in cardiovascular medicine
Author(s)
Longchamp A., MacArthur M.R., Trocha K., Ganahl J., Mann C.G., Kip P., King W.W., Sharma G., Tao M., Mitchell S.J., Ditrói T., Yang J., Nagy P., Ozaki C.K., Hine C., Mitchell J.R.
ISSN
2297-055X (Print)
ISSN-L
2297-055X
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
8
Pages
750926
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Objective: Hydrogen sulfide (H <sub>2</sub> S) is a gaseous signaling molecule and redox factor important for cardiovascular function. Deficiencies in its production or bioavailability are implicated in atherosclerotic disease. However, it is unknown if circulating H <sub>2</sub> S levels differ between vasculopaths and healthy individuals, and if so, whether H <sub>2</sub> S measurements can be used to predict surgical outcomes. Here, we examined: (1) Plasma H <sub>2</sub> S levels in patients undergoing vascular surgery and compared these to healthy controls, and (2) the association between H <sub>2</sub> S levels and mortality in a cohort of patients undergoing surgical revascularization. Methods: One hundred and fifteen patients undergoing carotid endarterectomy, open lower extremity revascularization or lower leg amputation were enrolled at a single institution. Peripheral blood was also collected from a matched control cohort of 20 patients without peripheral or coronary artery disease. Plasma H <sub>2</sub> S production capacity and sulfide concentration were measured using the lead acetate and monobromobimane methods, respectively. Results: Plasma H <sub>2</sub> S production capacity and plasma sulfide concentrations were reduced in patients with PAD (p < 0.001, p = 0.013, respectively). Patients that underwent surgical revascularization were divided into high vs. low H <sub>2</sub> S production capacity groups by median split. Patients in the low H <sub>2</sub> S production group had increased probability of mortality (p = 0.003). This association was robust to correction for potentially confounding variables using Cox proportional hazard models. Conclusion: Circulating H <sub>2</sub> S levels were lower in patients with atherosclerotic disease. Patients undergoing surgical revascularization with lower H <sub>2</sub> S production capacity, but not sulfide concentrations, had increased probability of mortality within 36 months post-surgery. This work provides insight on the role H <sub>2</sub> S plays as a diagnostic and potential therapeutic for cardiovascular disease.
Keywords
biomarker, hydrogen sulfide, limb ischemia, peripheral artery disease (PAD), surgery
Pubmed
Web of science
Open Access
Yes
Create date
18/07/2022 9:33
Last modification date
19/07/2022 6:36
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