Intrahemispheric cortico-cortical connections of the human auditory cortex.

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Serval ID
serval:BIB_A6E02C073736
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intrahemispheric cortico-cortical connections of the human auditory cortex.
Journal
Brain Structure and Function
Author(s)
Cammoun L., Thiran J.P., Griffa A., Meuli R., Hagmann P., Clarke S.
ISSN
1863-2661 (Electronic)
ISSN-L
1863-2653
Publication state
Published
Issued date
11/2015
Peer-reviewed
Oui
Volume
220
Number
6
Pages
3537-3553
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The human auditory cortex comprises the supratemporal plane and large parts of the temporal and parietal convexities. We have investigated the relevant intrahemispheric cortico-cortical connections using in vivo DSI tractography combined with landmark-based registration, automatic cortical parcellation and whole-brain structural connection matrices in 20 right-handed male subjects. On the supratemporal plane, the pattern of connectivity was related to the architectonically defined early-stage auditory areas. It revealed a three-tier architecture characterized by a cascade of connections from the primary auditory cortex to six adjacent non-primary areas and from there to the superior temporal gyrus. Graph theory-driven analysis confirmed the cascade-like connectivity pattern and demonstrated a strong degree of segregation and hierarchy within early-stage auditory areas. Putative higher-order areas on the temporal and parietal convexities had more widely spread local connectivity and long-range connections with the prefrontal cortex; analysis of optimal community structure revealed five distinct modules in each hemisphere. The pattern of temporo-parieto-frontal connectivity was partially asymmetrical. In conclusion, the human early-stage auditory cortical connectivity, as revealed by in vivo DSI tractography, has strong similarities with that of non-human primates. The modular architecture and hemispheric asymmetry in higher-order regions is compatible with segregated processing streams and lateralization of cognitive functions.
Keywords
Adult, Auditory Cortex/anatomy & histology, Cerebral Cortex/anatomy & histology, Diffusion Magnetic Resonance Imaging, Humans, Image Processing, Computer-Assisted, Male, Neural Pathways/anatomy & histology, White Matter/anatomy & histology, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
10/09/2014 14:28
Last modification date
20/08/2019 16:11
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