Intrathecal baclofen bolus complicated by deep vein thrombosis and pulmonary embolism. A case report.

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State: Public
Version: Final published version
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Serval ID
serval:BIB_A6A5A758C4D5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Intrathecal baclofen bolus complicated by deep vein thrombosis and pulmonary embolism. A case report.
Journal
European Journal of Physical and Rehabilitation Medicine
Author(s)
Carda S., Cazzaniga M., Taiana C., Pozzi R.
ISSN
1973-9087 (Print)
ISSN-L
1973-9087
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
44
Number
1
Pages
87-88
Language
english
Notes
Publication types: Case Reports ; Journal Article Publication Status: ppublish
Abstract
The aim of this study was to present a case of deep vein thrombosis (DVT) and pulmonary embolism (PE) after an intrathecal baclofen bolus test. The study was carried out at a tertiary care rehabilitation center in Italy, and it reports a case of a 65-year-old woman affected by primary lateral sclerosis, with lower limb spasticity, who underwent an intrathecal baclofen bolus trial. After a 100 microg baclofen test, she developed hypotension and oxygen desaturation lasting two days. A Doppler ultrasonography was positive for DVT, and echocardiography confirmed the diagnosis of PE. A Doppler ultrasonography performed before the test was negative. This is the first report in the literature of DVT and PE after an intrathecal baclofen bolus trial. Clinicians and patients should be informed that the intrathecal baclofen bolus trial procedure could be associated with rare but important risks such as DVT and PE, and they should be alert in recognizing potentially life-threatening complications.
Keywords
Aged, Baclofen/administration & dosage, Baclofen/adverse effects, Diagnosis, Differential, Echocardiography, Female, Humans, Injections, Motor Neuron Disease/complications, Muscle Relaxants, Central/administration & dosage, Muscle Relaxants, Central/adverse effects, Muscle Spasticity/drug therapy, Muscle Spasticity/etiology, Pulmonary Embolism/chemically induced, Pulmonary Embolism/diagnosis, Ultrasonography, Doppler, Venous Thrombosis/chemically induced, Venous Thrombosis/diagnosis
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25/03/2013 18:22
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15/07/2020 6:26
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