Association between C-reactive protein and adiposity in women.

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State: Public
Version: author
Serval ID
serval:BIB_A69EB62E1EDA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association between C-reactive protein and adiposity in women.
Journal
Journal of Clinical Endocrinology and Metabolism
Author(s)
Bochud M., Marquant F., Marques-Vidal P.M., Vollenweider P., Beckmann J.S., Mooser V., Paccaud F., Rousson V.
ISSN
0021-972X
ISSN-L
0021-972X
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
94
Number
10
Pages
3969-3977
Language
english
Abstract
Context: The link between C-reactive protein (CRP) and adiposity deserves to be further explored considering the controversial diabetogenic role of CRP. Objective: We explored the potential causal role of CRP on measures of adiposity. Design: We used a Mendelian randomization approach with the CRP and LEPR genes as instrumental variables in a cross-sectional Caucasian population-based study comprising 2526 men and 2836 women. Adiposity was measured using body mass index (BMI), fat and lean mass estimated by bioelectrical impedance, and waist circumference. Results: Log-transformed CRP explained by the rs7553007 SNP tagging the CRP gene was significantly associated with BMI (regression coefficient: 1.22 [0.18;2.25], P=0.02) and fat mass (2.67 [0.65;4.68], P=0.01), but not with lean mass in women, whereas no association was found in men. Log-transformed CRP explained by the rs1805096 LEPR SNP was also positively associated, although not significantly, with BMI or fat mass. The combined CRP-LEPR instrument explained 2.24% and 0.77% of CRP variance in women and in men, respectively. Log-transformed CRP explained by this combined instrument was significantly associated with BMI (0.98 [0.32;1.63], P=0.004), fat mass (2.07 [0.79;3.34], P=0.001) and waist (2.09 [0.39;3.78], P=0.01) in women, but not in men. Conclusion: Our data suggest that CRP is causally and positively related to BMI in women, and that this is mainly due to fat mass. Results on the combined CRP-LEPR instrument suggest that leptin may play a role in the causal association between CRP and adiposity in women. Results in men were not significant.
Keywords
Colaus Study , Adipose Tissue/metabolism* , Adiposity , Adult , Aged , Body Mass Index* , C-Reactive Protein/genetics* , C-Reactive Protein/metabolism* , Female , Genotype , Humans , Leptin/metabolism , Male , Middle Aged , Obesity/genetics, Obesity/metabolism* , Polymorphism, Single Nucleotide* , Research Design , Sex Factors , Waist Circumference
Pubmed
Web of science
Open Access
Yes
Create date
17/07/2009 10:34
Last modification date
20/08/2019 16:11
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