Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_A695D953CF31
Type
Article: article from journal or magazin.
Collection
Publications
Title
Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study.
Journal
World journal of psychiatry
Author(s)
Ajdacic-Gross V., Aleksandrowicz A., Rodgers S., Mutsch M., Tesic A., Müller M., Kawohl W., Rössler W., Seifritz E., Castelao E., Strippoli M.F., Vandeleur C., von Känel R., Paolicelli R., Landolt M.A., Witthauer C., Lieb R., Preisig M.
ISSN-L
2220-3206
Publication state
Published
Issued date
22/12/2016
Peer-reviewed
Oui
Volume
6
Number
4
Pages
419-430
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license
Abstract
To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.
We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety (early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects.
Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders (men), and measles/mumps/rubella-infections with early and late anxiety disorders (women). Gastric inflammatory diseases took effect in mood disorders (both sexes) and in early disorders (men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne (associations with mood disorders in men) and psoriasis (associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders (men), and neurodevelopmental and early anxiety disorders (women).
Infectious, atopic and inflammatory diseases are important risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced.

Pubmed
Open Access
Yes
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13/02/2017 17:17
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27/09/2019 8:55
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