Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe.

Details

Serval ID
serval:BIB_A66490D09189
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe.
Journal
European journal of cancer
Author(s)
Kroese T.E., van Hillegersberg R., Schoppmann S., Deseyne PRAJ, Nafteux P., Obermannova R., Nordsmark M., Pfeiffer P., Hawkins M.A., Smyth E., Markar S., Hanna G.B., Cheong E., Chaudry A., Elme A., Adenis A., Piessen G., Gani C., Bruns C.J., Moehler M., Liakakos T., Reynolds J., Morganti A., Rosati R., Castoro C., D'Ugo D., Roviello F., Bencivenga M., de Manzoni G., Jeene P., van Sandick J.W., Muijs C., Slingerland M., Nieuwenhuijzen G., Wijnhoven B., Beerepoot L.V., Kolodziejczyk P., Polkowski W.P., Alsina M., Pera M., Kanonnikoff T.F., Nilsson M., Guckenberger M., Monig S., Wagner D., Wyrwicz L., Berbee M., Gockel I., Lordick F., Griffiths E.A., Verheij M., van Rossum PSN, van Laarhoven HWM
Working group(s)
OMEC working group
Contributor(s)
Rosman C., Rütten H., Gootjes E.C., Vonken FEM, van Dieren J.M., Vollebergh M.A., van der Sangen M., Creemers G.J., Zander T., Schlößer H., Cascinu S., Mazza E., Nicoletti R., Damascelli A., Slim N., Passoni P., Cossu A., Puccetti F., Barbieri L., Fanti L., Azzolini F., Ventoruzzo F., Szczepanik A., Visa L., Reig A., Roques T., Harrison M., Ciseł B., Pikuła A., Skórzewska M., Vanommeslaeghe H., Van Daele E., Pattyn P., Geboes K., Callebout E., Ribeiro S., van Duijvendijk P., Tromp C., Sosef M., Warmerdam F., Heisterkamp J., Heisterkamp J., Vera A., Jordá E., López-Mozos F., Fernandez-Moreno M.C., Barrios-Carvajal M., Huerta M., de Steur W., Lips I., Diez M., Castro S., O'Neill R., Holyoake D., Hacker U., Denecke T., Kuhnt T., Hoffmeister A., Kluge R., Bostel T., Grimminger P., Jedlička V., Křístek J., Pospíšil P., Mourregot A., Maurin C., Starling N., Chong I.
ISSN
1879-0852 (Electronic)
ISSN-L
0959-8049
Publication state
Published
Issued date
03/2022
Peer-reviewed
Oui
Volume
164
Pages
18-29
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Consensus about the definition and treatment of oligometastatic oesophagogastric cancer is lacking.
To assess the definition and treatment of oligometastatic oesophagogastric cancer across multidisciplinary tumour boards (MDTs) in Europe.
European expert centers (n = 49) were requested to discuss 15 real-life cases in their MDT with at least a medical, surgical, and radiation oncologist present. The cases varied in terms of location and number of metastases, histology, timing of detection (i.e. synchronous versus metachronous), primary tumour treatment status, and response to systemic therapy. The primary outcome was the agreement in the definition of oligometastatic disease at diagnosis and after systemic therapy. The secondary outcome was the agreement in treatment strategies. Treatment strategies for oligometastatic disease were categorised into upfront local treatment (i.e. metastasectomy or stereotactic radiotherapy), systemic therapy followed by restaging to consider local treatment or systemic therapy alone. The agreement across MDTs was scored to be either absent/poor (<50%), fair (50%-75%), or consensus (≥75%).
A total of 47 MDTs across 16 countries fully discussed the cases (96%). Oligometastatic disease was considered in patients with 1-2 metastases in either the liver, lung, retroperitoneal lymph nodes, adrenal gland, soft tissue or bone (consensus). At follow-up, oligometastatic disease was considered after a median of 18 weeks of systemic therapy when no progression or progression in size only of the oligometastatic lesion(s) was seen (consensus). If at restaging after a median of 18 weeks of systemic therapy the number of lesions progressed, this was not considered as oligometastatic disease (fair agreement). There was no consensus on treatment strategies for oligometastatic disease.
A broad consensus on definitions of oligometastatic oesophagogastric cancer was found among MDTs of oesophagogastric cancer expert centres in Europe. However, high practice variability in treatment strategies exists.
Keywords
Europe, Humans, Lymph Nodes, Metastasectomy, Neoplasm Metastasis, Neoplasms, Radiosurgery, Gastric neoplasm, Neoplasm metastasis, Oesophageal neoplasm, Oligometastasis
Pubmed
Web of science
Open Access
Yes
Create date
12/02/2022 14:32
Last modification date
17/10/2022 5:40
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