NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels.

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Serval ID
serval:BIB_A63D15EF48B9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels.
Journal
Plos One
Author(s)
Grandclément C., Pick H., Vogel H., Held W.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
11
Number
3
Pages
e0151031
Language
english
Abstract
Natural Killer (NK) cells mediate innate immunity to infected and transformed cells. Yet, NK cells can also mount hapten-specific recall responses thereby contributing to contact hypersensitivity (CHS). However, since NK cells lack antigen receptors that are used by the adaptive immune system to recognize haptens, it is not clear if NK cells respond directly to haptens and, if so, what mediates these responses. Here we show that among four haptens the two that are known to induce NK cell-dependent CHS trigger the rapid influx of extracellular Ca2+ into NK cells and lymphocyte cell lines. Thus lymphocytes can respond to haptens independent of antigen presentation and antigen receptors. We identify the Ca2+-permeable cation channel TRPC3 as a component of the lymphocyte response to one of these haptens. These data suggest that the response to the second hapten is based on a distinct mechanism, consistent with the capacity of NK cells to discriminate haptens. These findings raise the possibility that antigen-receptor independent activation of immune cells contributes to CHS.
Pubmed
Web of science
Open Access
Yes
Create date
22/03/2016 19:45
Last modification date
07/04/2021 6:34
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