Determination of compliance with riboflavin in an antidepressive therapy

Details

Serval ID
serval:BIB_A62E0C20F264
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Determination of compliance with riboflavin in an antidepressive therapy
Journal
Arzneimittelforschung
Author(s)
Tinguely Dominique, Jonzier Michèle, Schopf Josef, Koeb L.iliane, Baumann Pierre
ISSN
0004-4172 (Print)
ISSN-L
0004-4172
Publication state
Published
Issued date
1985
Volume
35
Number
2
Pages
536-8
Language
english
Notes
Tinguely, D
Jonzier, M
Schopf, J
Koeb, L
Baumann, P
eng
Germany
Arzneimittelforschung. 1985;35(2):536-8.
Abstract
In a comprehensive study on the fate of amitriptyline (At, Laroxyl) in depressive patients, it was investigated whether their compliance could be controlled in analysing the concentration of riboflavin (vitamin B2) in urine. Therefore, they were medicated for 3 weeks with special tablets (Ro 4-1575/063) containing 150 mg At and 15 mg riboflavin. Different modalities or urine samplings were designed in order to establish the optimal conditions for testing compliance. Riboflavin, creatinine, At and nortriptyline were measured in urine, the tricyclic drugs also in plasma. The results show that compliance could be tested in analysing urine before and 4 h after the intake of the drug. However, this design was associated with a considerable subjective constraint for the patient.
Keywords
Adult, Amitriptyline/*therapeutic use/urine, Creatinine/urine, Depressive Disorder/*drug therapy/psychology, Drug Combinations, Female, Half-Life, Humans, Male, Middle Aged, Nortriptyline/urine, *Patient Compliance, *Riboflavin/urine
Pubmed
Create date
11/01/2021 11:35
Last modification date
25/01/2021 6:28
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