Bystander-Activated Memory CD8 T Cells Control Early Pathogen Load in an Innate-like, NKG2D-Dependent Manner.

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Version: author
Serval ID
serval:BIB_A606CA61CD6C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bystander-Activated Memory CD8 T Cells Control Early Pathogen Load in an Innate-like, NKG2D-Dependent Manner.
Journal
Cell Reports
Author(s)
Chu T., Tyznik A.J., Roepke S., Berkley A.M., Woodward-Davis A., Pattacini L., Bevan M.J., Zehn D., Prlic M.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
3
Number
3
Pages
701-708
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Report
Abstract
During an infection the antigen-nonspecific memory CD8 T cell compartment is not simply an inert pool of cells, but becomes activated and cytotoxic. It is unknown how these cells contribute to the clearance of an infection. We measured the strength of T cell receptor (TCR) signals that bystander-activated, cytotoxic CD8 T cells (BA-CTLs) receive in vivo and found evidence of limited TCR signaling. Given this marginal contribution of the TCR, we asked how BA-CTLs identify infected target cells. We show that target cells express NKG2D ligands following bacterial infection and demonstrate that BA-CTLs directly eliminate these target cells in an innate-like, NKG2D-dependent manner. Selective inhibition of BA-CTL-mediated killing led to a significant defect in pathogen clearance. Together, these data suggest an innate role for memory CD8 T cells in the early immune response before the onset of a de novo generated, antigen-specific CD8 T cell response.
Pubmed
Web of science
Open Access
Yes
Create date
23/04/2013 16:44
Last modification date
20/08/2019 15:11
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