Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment.

Details

Serval ID
serval:BIB_A5F10E941EA5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment.
Journal
Advanced science
Author(s)
Lienemann P.S., Vallmajo-Martin Q., Papageorgiou P., Blache U., Metzger S., Kiveliö A.S., Milleret V., Sala A., Hoehnel S., Roch A., Reuten R., Koch M., Naveiras O., Weber F.E., Weber W., Lutolf M.P., Ehrbar M.
ISSN
2198-3844 (Print)
ISSN-L
2198-3844
Publication state
Published
Issued date
04/2020
Peer-reviewed
Oui
Volume
7
Number
7
Pages
1903395
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The treatment of bone defects with recombinant bone morphogenetic protein-2 (BMP-2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low-dose BMP-2-based bone regeneration by mobilizing healing-associated mesenchymal progenitor cells (MPCs). Smart synthetic hydrogels are used to trap and study endogenous MPCs trafficking to bone defects. Hydrogel-trapped and prospectively isolated MPCs differentiate into multiple lineages in vitro and form bone in vivo. In vitro screenings reveal that platelet-derived growth factor BB (PDGF-BB) strongly recruits prospective MPCs making it a promising candidate for the engineering of hydrogels that enrich endogenous MPCs in vivo. However, PDGF-BB inhibits BMP-2-mediated osteogenesis both in vitro and in vivo. In contrast, smart two-way dynamic release hydrogels with fast-release of PDGF-BB and sustained delivery of BMP-2 beneficially promote the healing of bone defects. Collectively, it is shown that modulating the dynamics of endogenous progenitor cells in vivo by smart synthetic hydrogels significantly improves bone healing and holds great potential for other advanced applications in regenerative medicine.
Keywords
bone healing, bone morphogenetic proteins, growth factors, hydrogels, progenitor cells
Pubmed
Web of science
Open Access
Yes
Create date
10/10/2022 23:14
Last modification date
11/10/2022 5:39
Usage data