The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia.

Details

Serval ID
serval:BIB_A5EFBEFB20CB
Type
Article: article from journal or magazin.
Collection
Publications
Title
The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia.
Journal
Psychiatry research
Author(s)
Cropley V.L., Scarr E., Fornito A., Klauser P., Bousman C.A., Scott R., Cairns M.J., Tooney P.A., Pantelis C., Dean B.
ISSN
1872-7123 (Electronic)
ISSN-L
0165-1781
Publication state
Published
Issued date
30/11/2015
Peer-reviewed
Oui
Volume
234
Number
2
Pages
182-187
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Previous research has demonstrated that individuals with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism (rs2067477) within the cholinergic muscarinic M1 receptor (CHRM1) perform less well on the Wisconsin Card Sorting Test (WCST) than those who are heterozygous. This study sought to determine whether variation in the rs2067477 genotype was associated with differential changes in brain structure. Data from 227 patients with established schizophrenia or schizoaffective disorder were obtained from the Australian Schizophrenia Research Bank. Whole-brain voxel-based morphometry was performed to compare regional grey matter volume (GMV) between the 267C/C (N=191) and 267C/A (N=36) groups. Secondary analyses tested for an effect of genotype on cognition (the WCST was not available). Individuals who were homozygous (267C/C) demonstrated significantly reduced GMV in the right precentral gyrus compared to those who were heterozygous (267C/A). These preliminary results suggest that the rs2067477 genotype is associated with brain structure in the right precentral gyrus in individuals with schizophrenia/schizoaffective disorder. Future studies are required to replicate these results and directly link the volumetric reductions with specific cognitive processes.
Keywords
Adult, Australia/epidemiology, Cognition Disorders/diagnosis, Cognition Disorders/epidemiology, Cognition Disorders/genetics, Female, Genetic Variation/genetics, Gray Matter/pathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Organ Size, Polymorphism, Single Nucleotide/genetics, Receptor, Muscarinic M1/genetics, Schizophrenia/diagnosis, Schizophrenia/epidemiology, Schizophrenia/genetics, Imaging, Muscarinic M1 receptor (CHRM1), Schizoaffective disorder, Schizophrenia, Set-shifting, Single nucleotide polymorphism, Voxel-based morphometry
Pubmed
Web of science
Create date
07/02/2019 10:22
Last modification date
02/09/2019 6:26
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