High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis

Details

Ressource 1Download: serval:BIB_A58772576322.P001 (150.00 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_A58772576322
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis
Journal
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Author(s)
Trendelenburg M., Lopez-Trascasa M., Potlukova E., Moll S., Regenass S., Frémeaux-Bacchi V., Martinez-Ara J., Jancova E., Picazo M.L., Honsova E., Tesar V., Sadallah S., Schifferli J.
ISSN
0931-0509 (Print)
ISSN-L
0931-0509
Publication state
Published
Issued date
2006
Volume
21
Number
11
Pages
3115-3121
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: Anti-C1q antibodies (anti-C1q) have been shown to correlate positively with systemic lupus erythematosus (SLE) nephritis. Several clinical studies indicated a high negative predictive value, suggesting that active lupus nephritis is rarely seen in patients with no anti-C1q. However, the true prevalence of anti-C1q at the time of active lupus nephritis has not been well established. The aim of this study was to determine prospectively the prevalence of anti-C1q in proven active lupus nephritis at the time of the renal biopsy.
METHODS: In this prospective multi-centre study, we investigated adult SLE patients undergoing renal biopsy for suspected active lupus nephritis. Serum samples were taken at the time of the biopsy and analysed for the presence of anti-C1q in a standardized way. The activity of lupus nephritis was classified according to the renal histology. Biopsies were also analysed for the presence of glomerular IgG, C1q and C3 deposition.
RESULTS: A total of 38 patients fulfilling at least 4/11 American College of Rheumatology (ACR) criteria for the diagnosis of SLE were included. Out of this, 36 patients had proliferative (class II, III or IV) and two had class V lupus nephritis. All but one patient with proliferative lupus nephritis were positive for anti-C1q (97.2%) compared with the 35% of control SLE patients with inactive lupus nephritis and 25% of SLE patients without lupus nephritis ever. All patients were positive for glomerular C1q (36/36) and 37/38 patients had glomerular IgG deposits. Anti-C1q strongly decreased during successful treatment.
CONCLUSIONS: Anti-C1q have a very high prevalence in biopsy-proven active lupus nephritis, thus a negative test result almost excludes active nephritis. The data support the hypothesis of a pathogenic role of anti-C1q in lupus nephritis.
Keywords
Autoantibodies/blood, Complement C1q/immunology, Kidney/pathology, Lupus Erythematosus, Systemic/diagnosis, Lupus Erythematosus, Systemic/immunology, Lupus Erythematosus, Systemic/pathology, Lupus Nephritis/diagnosis, Lupus Nephritis/immunology, Lupus Nephritis/pathology
Pubmed
Web of science
Open Access
Yes
Create date
13/07/2018 9:00
Last modification date
25/09/2019 6:10
Usage data