The ubiquitin-proteasome system in glioma cell cycle control.

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State: Public
Version: author
Serval ID
serval:BIB_A523B91DFEBC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The ubiquitin-proteasome system in glioma cell cycle control.
Journal
Cell Division
Author(s)
Vlachostergios P.J., Voutsadakis I.A., Papandreou C.N.
ISSN
1747-1028 (Electronic)
ISSN-L
1747-1028
Publication state
Published
Issued date
2012
Volume
7
Number
18
Pages
1-6
Language
english
Notes
Publication types: Journal ArticlePublication Status: epublish. Authors' contributions: PJV performed literature review and drafted the manuscript. IAV and CNP revised and approved the final manuscript. All authors read and approved the final manuscript.
Abstract
A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) constitutes a universal protein degradation pathway, essential for the consistent recycling of a plethora of proteins with distinct structural and functional roles within the cell, including cell cycle regulation. High grade tumors, such as glioblastomas have an inherent potential of escaping cell cycle control mechanisms and are often refractory to conventional treatment. Here, we review the association of UPS with several UPS-targeted proteins and pathways involved in regulation of the cell cycle in malignant gliomas, and discuss the potential role of UPS inhibitors in reinstitution of cell cycle control.
Pubmed
Web of science
Open Access
Yes
Create date
15/11/2012 18:44
Last modification date
20/08/2019 15:10
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