An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing.

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Version: Final published version
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Serval ID
serval:BIB_A5215CD5F4B5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing.
Journal
Nature communications
Author(s)
Sánchez-Alcañiz J.A., Silbering A.F., Croset V., Zappia G., Sivasubramaniam A.K., Abuin L., Sahai S.Y., Münch D., Steck K., Auer T.O., Cruchet S., Neagu-Maier G.L., Sprecher S.G., Ribeiro C., Yapici N., Benton R.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
12/10/2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
4252
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Through analysis of the Drosophila ionotropic receptors (IRs), a family of variant ionotropic glutamate receptors, we reveal that most IRs are expressed in peripheral neuron populations in diverse gustatory organs in larvae and adults. We characterise IR56d, which defines two anatomically-distinct neuron classes in the proboscis: one responds to carbonated solutions and fatty acids while the other represents a subset of sugar- and fatty acid-sensing cells. Mutational analysis indicates that IR56d, together with the broadly-expressed co-receptors IR25a and IR76b, is essential for physiological responses to carbonation and fatty acids, but not sugars. We further demonstrate that carbonation and fatty acids both promote IR56d-dependent attraction of flies, but through different behavioural outputs. Our work provides a toolkit for investigating taste functions of IRs, defines a subset of these receptors required for carbonation sensing, and illustrates how the gustatory system uses combinatorial expression of sensory molecules in distinct neurons to coordinate behaviour.
Erratum with Publisher Correction: An Expression Atlas of Variant Ionotropic Glutamate Receptors Identifies a Molecular Basis of Carbonation Sensing
JA Sánchez-Alcañiz et al. Nat Commun 11 (1), 1131. 2020. PMID 32098953.
Keywords
Animals, Behavior, Animal/physiology, Carbonates/metabolism, Drosophila Proteins/genetics, Drosophila Proteins/metabolism, Drosophila melanogaster, Fatty Acids/metabolism, Neurons/cytology, Neurons/metabolism, Receptors, Ionotropic Glutamate/genetics, Receptors, Ionotropic Glutamate/metabolism, Taste/genetics, Taste/physiology
Pubmed
Web of science
Open Access
Yes
Create date
09/03/2018 9:00
Last modification date
29/02/2020 7:17
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