Effect of indomethacin on the renal response to angiotensin II receptor blockade in healthy subjects.

Details

Serval ID
serval:BIB_A519C63983E5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effect of indomethacin on the renal response to angiotensin II receptor blockade in healthy subjects.
Journal
Kidney international
Author(s)
Fricker A.F., Nussberger J., Meilenbrock S., Brunner H.R., Burnier M.
ISSN
0085-2538
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
54
Number
6
Pages
2089-97
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
BACKGROUND: Non-steroidal anti-inflammatory drugs are known to promote sodium retention and to blunt the blood pressure lowering effects of several classes of antihypertensive agents including beta-blockers, diuretics and angiotensin converting enzyme (ACE) inhibitors. The purpose of the present study was to investigate the acute and sustained effects of indomethacin on the renal response to the angiotensin II receptor antagonist valsartan and to the ACE inhibitor enalapril. METHODS: Twenty normotensive subjects maintained on fixed sodium intake (100 mmol sodium/day) were randomized to receive for one week: valsartan 80 mg o.d., enalapril 20 mg o.d., valsartan 80 mg o.d. + indomethacin 50 mg bid and enalapril 20 mg o.d. + indomethacin 50 mg bid. This single-blind study was designed as a parallel (valsartan vs. enalapril) and cross-over trial (valsartan or enalapril vs. valsartan + indomethacin or enalapril + indomethacin). Renal hemodynamics and urinary electrolyte excretion were measured for six hours after the first and seventh administration of each treatment regimen. RESULTS: The results show that valsartan and enalapril have comparable renal effects characterized by no change in glomerular filtration rate and significant increases in renal plasma flow and sodium excretion. The valsartan- and enalapril-induced renal vasodilation is not significantly blunted by indomethacin. However, indomethacin similarly abolishes the natriuresis induced by the angiotensin II antagonist and the ACE inhibitor. CONCLUSIONS: This observation suggests that although angiotensin receptor antagonists do not affect prostaglandin metabolism, the administration of a non-steroidal anti-inflammatory drug blunts the natriuretic response to angiotensin receptor blockade.
Keywords
Adult, Angiotensin-Converting Enzyme Inhibitors, Anti-Inflammatory Agents, Non-Steroidal, Cross-Over Studies, Enalapril, Humans, Indomethacin, Kidney, Male, Natriuresis, Receptors, Angiotensin, Reference Values, Renal Circulation, Single-Blind Method, Tetrazoles, Valine
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2008 17:41
Last modification date
20/08/2019 16:10
Usage data