Heritability of the retinal microcirculation in flemish families.

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Serval ID
serval:BIB_A50FD0BFF2D8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Heritability of the retinal microcirculation in flemish families.
Journal
American Journal of Hypertension
Author(s)
Liu Y.P., Kuznetsova T., Jin Y., Thijs L., Asayama K., Gu Y.M., Bochud M., Verhamme P., Struijker-Boudier H.A., Staessen J.A.
ISSN
1941-7225 (Electronic)
ISSN-L
0895-7061
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
26
Number
3
Pages
392-399
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
BACKGROUND Few population studies have described the heritability and intrafamilial concordance of the retinal microvessels, or the genetic or environmental correlations of the phenotypes of these vessels. METHODS We randomly selected 413 participants from 70 families (mean age, 51.5 years; 50.1% women) from a Flemish population. We postprocessed retinal images using IVAN software to generate the central retinal arteriole equivalent (CRAE), central retinal venule equivalent (CRVE), and arteriole-to-venule-ratio (AVR) from these images. We used SAGE version 6.2 and SAS version 9.2 to compute multivariate-adjusted estimates of heritability and intrafamilial correlations of the CRAE, CRVE, and AVR of the retinal microvessels in the images. RESULTS Sex, age, mean arterial pressure, and smoking explained up to 12.7% of the variance of the phenotypes of the retinal microvessels of the study participants. With adjustments applied for these covariates, the heritability estimates of CRAE, CRVE, and AVR were 0.213 (P = 0.044), 0.339 (P = 0.010), and 0.272 (P = 0.004), respectively. The parent-offspring correlations for CRAE, CRVE, and AVR were 0.118 (NS), 0.225 (P < 0.01), and 0.215 (P < 0.05), respectively. The corresponding values were 0.222 (P < 0.05), 0.213 (P < 0.05), and 0.390 (P < 0.001) for sib-sib correlations, respectively. The genetic and environmental correlations between CRAE and CRVE were 0.360 and 0.545 (P < 0.001 for both). CONCLUSION Our study showed moderate heritability for CRAE, CRVE, and AVR, and a significant genetic correlation of CRAE with CRVE in the Flemish population of our study. These findings suggest that genetic factors influence the diameter of the retinal microvessels, and that CRAE and CRVE share some genetic determinants.
Pubmed
Web of science
Open Access
Yes
Create date
04/03/2013 16:24
Last modification date
20/08/2019 15:10
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