Oscillating Positive Airway Pressure Versus CPAP for the Treatment of Obstructive Sleep Apnea.

Details

Serval ID
serval:BIB_A4FAB0ED87E1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Oscillating Positive Airway Pressure Versus CPAP for the Treatment of Obstructive Sleep Apnea.
Journal
Frontiers In Medicine
Author(s)
Haba-Rubio J., Petitpierre N.J., Cornette F., Tobback N., Vat S., Giallourou T., Al-Jumaily A., Heinzer R.
ISSN
2296-858X (Electronic)
ISSN-L
2296-858X
Publication state
Published
Issued date
2015
Volume
2
Pages
29
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
Although continuous positive airway pressure (CPAP) is the most effective therapy for obstructive sleep apnea (OSA), it is not always well tolerated by the patients. Previous physiological studies showed that pressure oscillations applied to the pharynx could activate upper airway muscles, but it is not clear whether these pressure oscillations could be tolerated during sleep in OSA patients. The aim of this study was to assess the tolerance of oscillating positive airway pressure (O-PAP) (a CPAP device delivering high-frequency pressure oscillations to the upper airway) compared to CPAP. Fourteen OSA patients currently on CPAP [age 59.9 ± 10.1 years old, BMI 34.8 ± 7.2 kg/m(2), initial apnea-hypopnea index (AHI): 58.7 ± 25.2 events/h] used O-PAP or CPAP on two consecutive nights under polysomnography, in a single-blind randomized crossover design to assess sleep quality. A subtherapeutic pressure (70% of the optimal titrated pressure) was applied in both conditions and the residual AHI with each technique was also compared. There was no difference in measured or perceived sleep quality between the two treatment modalities (sleep efficiency 90.0% versus 88.1%, p = 0.54). Despite the small sample, we also found a trend toward a decrease in residual respiratory events with O-PAP compared to CPAP (median AHI 14.3 versus 20.5/h, p = 0.194). The good tolerance of O-PAP and the positive trend toward a reduction in residual AHI should stimulate further research on the effects of O-PAP in OSA patients.
Pubmed
Open Access
Yes
Create date
24/04/2016 9:37
Last modification date
19/11/2019 6:26
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