Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines.

Details

Serval ID
serval:BIB_A4B7EE94B270
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines.
Journal
Frontiers in Bioscience
Author(s)
Ruter J., Barnett B.G., Kryczek I., Brumlik M.J., Daniel B.J., Coukos G., Zou W., Curiel T.J.
ISSN
1093-4715 (Electronic)
ISSN-L
1093-4715
Publication state
Published
Issued date
2009
Volume
14
Pages
1761-1770
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: epublish
Abstract
Cancers express tumor associated antigens that should elicit immune attack, but spontaneous immune rejection of established cancer is rare. Recent data demonstrate that specific and active tumor-mediated mechanisms hinder host anti-tumor immunity. CD4+CD25+ T regulatory cells (Tregs) are important mediators of active immune evasion in cancer. Disrupting tumor-mediated mechanisms hindering host immunity is a novel approach to tumor immunotherapy. Treg depletion improves endogenous anti-tumor immunity and the efficacy of active immunotherapy in animal models for cancer, suggesting that inhibiting Treg function could also improve the limited successes of human cancer immunotherapy. We have identified five strategies to block Treg activity: depletion, interference with trafficking, inhibition of differentiation, blockade of function or raising the effector T cell threshold for suppression. Discovery of additional regulatory cell populations expands the potential targets for these approaches. The fusion toxin denileukin diftitox (Ontak) reduces Treg numbers and function in the blood of some patients with cancer. We discuss specific strategies to block Treg activity and present some of our preliminary data in this area. Combining Treg depletion with active vaccination and other approaches poses additional challenges that are discussed.
Keywords
Cancer Vaccines/therapeutic use, Cell Differentiation, Humans, Immunotherapy, Neoplasms/immunology, Neoplasms/pathology, T-Lymphocytes, Regulatory/cytology, T-Lymphocytes, Regulatory/immunology
Pubmed
Web of science
Create date
14/10/2014 11:43
Last modification date
20/08/2019 15:10
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