Retrograde neurotrophin-mediated control of neurone survival in the developing central nervous system.

Details

Serval ID
serval:BIB_A4B487A41844
Type
Article: article from journal or magazin.
Collection
Publications
Title
Retrograde neurotrophin-mediated control of neurone survival in the developing central nervous system.
Journal
Neuroreport
Author(s)
Primi M.P., Clarke P.G.H.
ISSN
0959-4965[print], 0959-4965[linking]
Publication state
Published
Issued date
1996
Volume
7
Number
2
Pages
473-476
Language
english
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jan 31
Abstract
Neuronal death in vertebrate development is widely believed to be regulated by retrograde survival signals from the axonal target territory, and these signals are assumed to be initiated by the binding of trophic molecules to the axon terminal. However, direct evidence for the retrograde transmission of such survival signals along developing axons is only available in the peripheral nervous system. We show here in a central projection, the isthmo-optic projection of chick embryos, that a neurotrophin, brain-derived neurotrophic factor, can indeed initiate retrograde survival signals from the target territory. A related molecule, neurotrophin-3, is ineffective.
Keywords
Animals, Brain-Derived Neurotrophic Factor/pharmacology, Cell Survival/physiology, Central Nervous System/cytology, Central Nervous System/growth & development, Chick Embryo, Excitatory Amino Acid Agonists/pharmacology, Kainic Acid/pharmacology, Nerve Growth Factors/pharmacology, Nerve Growth Factors/physiology, Neurons/physiology, Neurotrophin 3, Receptors, Nerve Growth Factor/drug effects, Visual Pathways/cytology, Visual Pathways/growth & development
Pubmed
Web of science
Create date
20/01/2008 18:49
Last modification date
20/08/2019 16:10
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