Sex-specific resting state brain network dynamics in patients with major depressive disorder.

Details

Serval ID
serval:BIB_A47434DCB529
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sex-specific resting state brain network dynamics in patients with major depressive disorder.
Journal
Neuropsychopharmacology
Author(s)
Dong D., Pizzagalli D.A., Bolton TAW, Ironside M., Zhang X., Li C., Sun X., Xiong G., Cheng C., Wang X., Yao S., Belleau E.L.
ISSN
1740-634X (Electronic)
ISSN-L
0893-133X
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Sex-specific neurobiological changes have been implicated in Major Depressive Disorder (MDD). Dysfunctions of the default mode network (DMN), salience network (SN) and frontoparietal network (FPN) are critical neural characteristics of MDD, however, the potential moderating role of sex on resting-state network dynamics in MDD has not been sufficiently evaluated. Thus, resting-state functional magnetic resonance imaging (fMRI) data were collected from 138 unmedicated patients with first-episode MDD (55 males) and 243 healthy controls (HCs; 106 males). Recurring functional network co-activation patterns (CAPs) were extracted, and time spent in each CAP (the total amount of volumes associated to a CAP), persistence (the average number of consecutive volumes linked to a CAP), and transitions across CAPs involving the SN, DMN and FPN were quantified. Relative to HCs, MDD patients exhibited greater persistence in a CAP involving activation of the DMN and deactivation of the FPN (DMN + FPN-). In addition, relative to the sex-matched HCs, the male MDD group spent more time in two CAPs involving the SN and DMN (i.e., DMN + SN- and DMN-SN + ) and transitioned more frequently from the DMN + FPN- CAP to the DMN + SN- CAP relative to the male HC group. Conversely, the female MDD group showed less persistence in the DMN + SN- CAP relative to the female HC group. Our findings highlight that the imbalance between SN and DMN could be a neurobiological marker supporting sex differences in MDD. Moreover, the dominance of the DMN accompanied by the deactivation of the FPN could be a sex-independent neurobiological correlate related to depression.
Pubmed
Web of science
Create date
18/01/2024 15:29
Last modification date
27/01/2024 7:36
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