Analysis of HIV-1- and CMV-specific memory CD4 T-cell responses during primary and chronic infection

Details

Serval ID
serval:BIB_A47337CF723B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Analysis of HIV-1- and CMV-specific memory CD4 T-cell responses during primary and chronic infection
Journal
Blood
Author(s)
Harari  A., Rizzardi  G. P., Ellefsen  K., Ciuffreda  D., Champagne  P., Bart  P. A., Kaufmann  D., Telenti  A., Sahli  R., Tambussi  G., Kaiser  L., Lazzarin  A., Perrin  L., Pantaleo  G.
ISSN
0006-4971 (Print)
Publication state
Published
Issued date
08/2002
Volume
100
Number
4
Pages
1381-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 15
Abstract
CD4 T-cell-specific memory antiviral responses to human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) were investigated in 16 patients with documented primary HIV-1 infection (4 of the 16 subjects also had primary CMV infection) and compared with those observed in patients with chronic HIV-1 and CMV coinfection. Virus-specific memory CD4 T cells were characterized on the basis of the expression of the chemokine receptor CCR7. HIV-1- and CMV-specific interferon-gamma-secreting CD4 T cells were detected in patients with primary and chronic HIV-1 and CMV coinfection and were mostly contained in the cell population lacking expression of CCR7. The magnitude of the primary CMV-specific CD4 T-cell response was significantly greater than that of chronic CMV infection, whereas there were no differences between primary and chronic HIV-1-specific CD4 T-cell responses. A substantial proportion of CD4(+)CCR7(-) T cells were infected with HIV-1. These results advance the characterization of antiviral memory CD4 T-cell response and the delineation of the potential mechanisms that likely prevent the generation of a robust CD4 T-cell immune response during primary infection.
Keywords
Acquired Immunodeficiency Syndrome/complications/*immunology Adult Antibodies, Viral/blood CD4-Positive T-Lymphocytes/*immunology Chronic Disease Cytomegalovirus/immunology Cytomegalovirus Infections/complications/*immunology Female HIV-1/*immunology Humans Immunologic Memory Male Phenotype Receptors, Chemokine/analysis Viral Load Viremia
Pubmed
Web of science
Create date
25/01/2008 15:00
Last modification date
20/08/2019 15:09
Usage data