Evaluation of laser flare-cell photometry in the appraisal and management of intraocular inflammation in uveitis

Details

Serval ID
serval:BIB_A4428179031B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of laser flare-cell photometry in the appraisal and management of intraocular inflammation in uveitis
Journal
Ophthalmology
Author(s)
Guex-Crosier  Y., Pittet  N., Herbort  C. P.
ISSN
0161-6420 (Print)
Publication state
Published
Issued date
04/1994
Volume
101
Number
4
Pages
728-35
Notes
Case Reports Comparative Study Journal Article --- Old month value: Apr
Abstract
BACKGROUND: Laser flare-cell photometry enables objective and quantitative measurement of anterior chamber inflammation. Systematic data currently are used mainly for clinical research; few are yet available in uveitis. The authors prospectively studied the amount, duration, and pattern of inflammation for well-defined uveitic conditions and evaluated the potential usefulness of laser flare-cell photometry in uveitis. METHODS: Mean initial flare was calculated in HLA-B27-positive acute anterior uveitis, acute herpes zoster uveitis, acute retinal necrosis (ARN), Fuchs heterochromic cyclitis, intermediate uveitis (pars planitis-type), posterior sarcoidosis, posterior pole toxoplasmosis, and birdshot chorioretinopathy. Evolution of aqueous flare and cells was analyzed for acute anterior uveitis, ARN, and pars planitis treated for cystoid macular edema (CME), all of which received a standardized therapy. RESULTS: Blood-aqueous barrier disruption was very pronounced in acute anterior uveitis (170.2 +/- 33 photons/msecond), ARN (177.4 +/- 88 photons/msecond), moderate in posterior sarcoidosis (38.1 +/- 11 photons/msecond), acute zoster uveitis (25.8 +/- 6.1 photons/msecond), and pars planitis (19.1 +/- 2.9 photons/msecond) but only minimal in Fuchs heterochromic cyclitis (10.2 +/- 3.5 photons/msecond), toxoplasmosis (9.0 +/- 1.2 photons/msecond) and birdshot chorioretinopathy (5.7 +/- 1.1 photons/msecond). For acute anterior uveitis, ARN, and pars planitis with CME, the inflammatory patterns were determined. The potential of laser flare-cell photometry for precise follow-up and adjustment of therapy was illustrated in cases of anterior and posterior uveitis. CONCLUSION: The authors' findings show that laser flare-cell photometry allows quantitative assessment of inflammation in uveitis and contributes to improved management of patients with uveitis.
Keywords
Adolescent Adult Aged Aged, 80 and over Cell Count Choroiditis/diagnosis Evaluation Studies Female HLA-B27 Antigen/analysis Humans Lasers/*diagnostic use Male Middle Aged Panuveitis/diagnosis Photometry/instrumentation Prospective Studies Uveitis/*diagnosis/therapy Uveitis, Anterior/diagnosis
Pubmed
Web of science
Create date
28/01/2008 12:45
Last modification date
20/08/2019 15:09
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