The opposing effects of chronic angiotensin-converting enzyme blockade by captopril on the responses to exogenous angiotensin II and vasopressin vs. norepinephrine in rats.

Details

Serval ID
serval:BIB_A416F91D0C0F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The opposing effects of chronic angiotensin-converting enzyme blockade by captopril on the responses to exogenous angiotensin II and vasopressin vs. norepinephrine in rats.
Journal
Circulation Research
Author(s)
Spertini F., Brunner H.R., Waeber B., Gavras H.
ISSN
0009-7330
Publication state
Published
Issued date
05/1981
Peer-reviewed
Oui
Volume
48
Number
5
Pages
612-618
Language
english
Notes
Journal Article --- Old month value: May
Abstract
To study the influence of acute and chronic angiotensin-converting enzyme blockade on the pressor response to exogenous angiotensin II, vasopressin and norepinephrine, we gave normal female Wistar rats 100 mg of captopril or 1 ml of 5% glucose twice daily by gavage for 2 weeks. On the 15th day, rats were anesthetized with pentobarbital, and dose-response curves to angiotensin II, lysine-vasopressin, and norepinephrine were obtained before and after intraperitoneal injection of 100 mg/kg of captopril or 1 ml of 5% glucose. Acute as well as chronic converting enzyme blockade enhanced the pressor response to exogenous angiotensin II. Similarly, sensitivity to exogenous vasopressin was increased by both acute and chronic converting enzyme inhibition. In contrast, chronic converting enzyme blockade significantly blunted the response to exogenous norepinephrine, whereas acute blockade tended to accentuate its pressor effect. These results suggest that chronic angiotensin-converting enzyme blockade may partly inhibit sympathetic activity which, in turn, might contribute to the antihypertensive efficacy of this therapeutic approach. These results also point to an important physiological interaction between the two pressor hormones, angiotensin II and vasopressin.
Keywords
Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Animals, Blood Pressure, Captopril, Dose-Response Relationship, Drug, Female, Lysine Vasopressin, Norepinephrine, Proline, Rats, Vasopressins
Pubmed
Web of science
Create date
25/01/2008 15:20
Last modification date
20/08/2019 15:09
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