Type 2 diabetes affects bone cells precursors and bone turnover.

Details

Serval ID
serval:BIB_A40FF7110763
Type
Article: article from journal or magazin.
Collection
Publications
Title
Type 2 diabetes affects bone cells precursors and bone turnover.
Journal
BMC endocrine disorders
Author(s)
Sassi F., Buondonno I., Luppi C., Spertino E., Stratta E., Di Stefano M., Ravazzoli M., Isaia G., Trento M., Passera P., Porta M., Isaia G.C., D'Amelio P.
ISSN
1472-6823 (Electronic)
ISSN-L
1472-6823
Publication state
Published
Issued date
08/08/2018
Peer-reviewed
Oui
Volume
18
Number
1
Pages
55
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Here we study the effect of type 2 diabetes (T2DM) on bone cell precursors, turnover and cytokines involved in the control of bone cell formation and activity.
We enrolled in the study 21 T2DM women and 21 non diabetic controls matched for age and body mass index (BMI). In each subject we measured bone cell precursors, Receptor Activator of Nuclear Factor κB (RANKL), Osteoprotegerin (OPG), Sclerostin (SCL) and Dickoppf-1 (DKK-1) as cytokines involved in the control of osteoblast and osteoclast formation and activity, bone density (BMD) and quality trough trabecular bone score (TBS) and bone turnover. T2DM patients and controls were compared for the analyzed variables by one way ANOVA for Gaussian ones and by Mann-Whitney or Kruskal-Wallis test for non-Gaussian variables.
RANKL was decreased and DKK-1 increased in T2DM. Accordingly, patients with T2DM have lower bone turnover compared to controls. BMD and TBS were not significantly different from healthy controls. Bone precursor cells were more immature in T2DM. However the number of osteoclast precursors was increased and that of osteoblasts decreased.
Patients with T2DM have more immature bone cells precursors, with increased number of osteoclasts and decreased osteoblasts, confirming low bone turnover and reduced cytokines such as RANKL and DKK-1. BMD and TBS are not significantly altered in T2DM although, in contrast with other studies, this may be due to the match of patients and controls for BMI rather than age.
Keywords
Aged, Biomarkers/blood, Bone Remodeling/physiology, Case-Control Studies, Diabetes Mellitus, Type 2/blood, Diabetes Mellitus, Type 2/diagnosis, Female, Humans, Intercellular Signaling Peptides and Proteins/blood, Male, Osteoblasts/metabolism, Osteoclasts/metabolism, RANK Ligand/blood, Bone density, Diabetes, Osteoblast, Osteoclast, Receptor activator of nuclear factor κB, Sclerostin
Pubmed
Web of science
Open Access
Yes
Create date
13/01/2020 15:42
Last modification date
14/01/2020 6:26
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