Molecular underpinning of extranodal NK/T-cell lymphoma.

Details

Serval ID
serval:BIB_A405864F1046
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Molecular underpinning of extranodal NK/T-cell lymphoma.
Journal
Best Practice and Research. Clinical Haematology
Author(s)
Huang Y., de Leval L., Gaulard P.
ISSN
1532-1924 (Electronic)
ISSN-L
1521-6926
Publication state
Published
Issued date
2013
Volume
26
Number
1
Pages
57-74
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Peripheral NK/T-cell lymphoma (PTCL) is a heterogeneous group of uncommon hematologic malignancies with aggressive clinical course and unfavorable prognosis. Extranodal NK/T-cell lymphoma, nasal type (NKTCL) is the most common extranodal entity worldwide, with heterogeneous geographic distribution, and it is characterized by its association with EBV, a nasal or less often extranasal presentation and aggressive behavior. Recent works using array-based technologies have provided novel insights into the pathogenesis and discovered new biomarkers with diagnostic and therapeutic implications in NKTCL. Gene expression profiling identified that most of the NKTCL are derived from activated natural killer cells with distinctively high expression of granzyme H compared to other PTCLs, which might serve as a new diagnostic biomarker. Frequent deletions and promoter methylations in PRDM1, ATG5, AIM1, FOXO3, HACE1 mapping to 6q21-q25, suggest their roles as potential tumor suppressors. The deregulation of oncogenic pathways (PDGF, JAK-STAT, AKT) provides a rationale for developing targeted therapies in the future.
Keywords
Extranodal NK/T-cell lymphoma, Natural killer, Tumor suppressor genes
Pubmed
Web of science
Create date
04/08/2013 8:35
Last modification date
20/08/2019 15:09
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