Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study.

Details

Ressource 1Download: BIB_A3F591D6E74E.P001.pdf (755.73 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_A3F591D6E74E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study.
Journal
Plos One
Author(s)
Hysek C.M., Simmler L.D., Nicola V.G., Vischer N., Donzelli M., Krähenbühl S., Grouzmann E., Huwyler J., Hoener M.C., Liechti M.E.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2012
Volume
7
Number
5
Pages
e36476
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
This study assessed the effects of the serotonin (5-HT) and norepinephrine (NE) transporter inhibitor duloxetine on the effects of 3,4-methylenedioxy-methamphetamine (MDMA, ecstasy) in vitro and in 16 healthy subjects. The clinical study used a double-blind, randomized, placebo-controlled, four-session, crossover design. In vitro, duloxetine blocked the release of both 5-HT and NE by MDMA or by its metabolite 3,4-methylenedioxyamphetamine from transmitter-loaded human cells expressing the 5-HT or NE transporter. In humans, duloxetine inhibited the effects of MDMA including elevations in circulating NE, increases in blood pressure and heart rate, and the subjective drug effects. Duloxetine inhibited the pharmacodynamic response to MDMA despite an increase in duloxetine-associated elevations in plasma MDMA levels. The findings confirm the important role of MDMA-induced 5-HT and NE release in the psychotropic effects of MDMA. Duloxetine may be useful in the treatment of psychostimulant dependence. TRIAL REGISTRATION: Clinicaltrials.gov NCT00990067.
Keywords
3,4-Methylenedioxyamphetamine/antagonists & inhibitors, 3,4-Methylenedioxyamphetamine/pharmacology, Adult, Biological Transport/drug effects, Female, Humans, Laboratories, Male, N-Methyl-3,4-methylenedioxyamphetamine/antagonists & inhibitors, Norepinephrine/secretion, Placebo Effect, Receptors, Adrenergic/metabolism, Serotonin/secretion, Serotonin Plasma Membrane Transport Proteins/metabolism, Thiophenes/adverse effects, Thiophenes/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
22/07/2012 21:20
Last modification date
20/08/2019 15:09
Usage data