Repair of critical size defects in the rat cranium using ceramic-reinforced PLA scaffolds obtained by supercritical gas foaming

Details

Serval ID
serval:BIB_A3F3B74A50FA
Type
Article: article from journal or magazin.
Collection
Publications
Title
Repair of critical size defects in the rat cranium using ceramic-reinforced PLA scaffolds obtained by supercritical gas foaming
Journal
Journal of Biomedical Materials Research. Part A
Author(s)
Montjovent  M. O., Mathieu  L., Schmoekel  H., Mark  S., Bourban  P. E., Zambelli  P. Y., Laurent-Applegate  L. A., Pioletti  D. P.
ISSN
1549-3296 (Print)
Publication state
Published
Issued date
10/2007
Volume
83
Number
1
Pages
41-51
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Abstract
Bioresorbable scaffolds made of poly(L-lactic acid) (PLA) obtained by supercritical gas foaming were recently described as suitable for tissue engineering, portraying biocompatibility with primary osteoblasts in vitro and interesting mechanical properties when reinforced with ceramics. The behavior of such constructs remained to be evaluated in vivo and therefore the present study was undertaken to compare different PLA/ceramic composite scaffolds obtained by supercritical gas foaming in a critical size defect craniotomy model in Sprague-Dawley rats. The host-tissue reaction to the implants was evaluated semiquantitatively and similar tendencies were noted for all graft substitutes: initially highly reactive but decreasing with time implanted. Complete bone-bridging was observed 18 weeks after implantation with PLA/ 5 wt % beta-TCP (PLA/TCP) and PLA/5 wt % HA (PLA/HA) scaffolds as assessed by histology and radiography. We show here for the first time that this solvent-free technique provides a promising approach in tissue engineering demonstrating both the biocompatibility and osteoconductivity of the processed structures in vivo.
Pubmed
Web of science
Create date
28/01/2008 13:29
Last modification date
20/08/2019 16:09
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