Congenital diaphragmatic hernia: current status and review of the literature.

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Serval ID
serval:BIB_A3D492EF7775
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Congenital diaphragmatic hernia: current status and review of the literature.
Journal
European Journal of Pediatrics
Author(s)
de Buys Roessingh A.S., Dinh-Xuan A.T.
ISSN
1432-1076[electronic]
Publication state
Published
Issued date
2009
Volume
168
Number
4
Pages
393-406
Language
english
Abstract
Treatment of congenital diaphragmatic hernia (CDH) challenges obstetricians, pediatric surgeons, and neonatologists. Persistent pulmonary hypertension (PPHT) associated with lung hypoplasia in CDH leads to a high mortality rate at birth. PPHT is principally due to an increased muscularization of the arterioles. Management of CDH has been greatly improved by the introduction of prenatal surgical intervention with tracheal obstruction (TO) and by more appropriate postnatal care. TO appears to accelerate fetal lung growth and to increase the number of capillary vessels and alveoli. Improvement of postnatal care over the last years is mainly due to the avoidance of lung injury by applying low peak inflation pressure during ventilation. The benefits of other drugs or technical improvements such as the use of inhaled nitric oxide or extracorporeal membrane oxygenation (ECMO) are still being debated and no single strategy is accepted worldwide. Despite intensive clinical and experimental research, the treatment of newborn with CDH remains difficult.
Keywords
Animals, Balloon Dilatation, Calcium Channel Blockers/therapeutic use, Comorbidity, Extracorporeal Membrane Oxygenation, Fetal Diseases/diagnosis, Fetal Diseases/surgery, Fetal Therapies/methods, Fetus, Gestational Age, Guanylate Cyclase/therapeutic use, Hernia, Diaphragmatic/congenital, Hernia, Diaphragmatic/diagnosis, Humans, Infant, Newborn, Nitric Oxide/therapeutic use, Persistent Fetal Circulation Syndrome/diagnosis, Persistent Fetal Circulation Syndrome/epidemiology, Phosphoric Diester Hydrolases/therapeutic use, Pulmonary Surgical Procedures/methods, Respiration, Artificial/methods, Surface-Active Agents/therapeutic use, Tracheal Stenosis/congenital, Tracheal Stenosis/diagnosis, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
27/06/2009 15:04
Last modification date
01/10/2019 6:19
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