Long-term survivors of childhood all: is health-related quality of life reduced in those who had suffered a relapse? : PQ.014

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State: Public
Version: author
Serval ID
serval:BIB_A3BC5DAE8867
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Long-term survivors of childhood all: is health-related quality of life reduced in those who had suffered a relapse? : PQ.014
Title of the conference
41st Annual Conference of the International Society of Paediatric Oncology
Author(s)
Essig Stefan, Rebholz Cornelia, Strippoli Marie-Pierre F., Michel Gisela, Von der Weid Nicolas X., Niggli Felix K., Kuehni Claudia E.
Address
Sao Paulo, Brazil, October 5-9, 2009
ISBN
1545-5009
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
53
Series
Pediatric Blood and Cancer
Pages
856-857
Language
english
Notes
Purpose: About 20% of children with acute lymphoblastic leukemia (ALL) suffer from a relapse and only 1/3 of these can be cured.We aimed to compare the long-term health-related quality of life (HRQOL) of ALL survivors with and without a relapse. Method: As part of the Swiss Childhood Cancer Survivor Study (SCCSS), we sent a questionnaire to all survivors of childhood ALL in Switzerland who had been diagnosed between 1976-2003 at an age of <16 years and who were currently aged older than 19 years. HRQOL was assessed with the SF-36 measuring 4 dimensions (scales) of physical health and 4 dimensions of mental health. A score of 50 corresponds to the mean of a healthy reference population. Results: From 396 ALL survivors eligible for the survey 318 (80%) participated until February 2009, but recruitment is still ongoing. Of these, 47 (15%) had had a relapse. Scores for all 8 domains were slightly higher in ALL survivors with and without relapse or similar compared to reference data from France and Germany (Swiss norm data unavailable). In five scales, scores did not differ between participants with and without relapse. Only in three scales (general health perceptions, role limitations due to physical health and vitality) scores in survivors with a relapse were slightly lower (48.4, 50.5 and 51.3 respectively) than in those without (53.8, 53.1 and 54.7 respectively; p¼0.001, 0.036 and 0.038). Conclusion: Although mortality in childhood ALL patients with a relapse is high, long-term HRQOL in those who survived is good, i.e. their HRQOL is comparable to both survivors without relapse and to the general population. The small differences found for three of eight scales will be further analyzed.
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Create date
08/12/2009 16:48
Last modification date
20/08/2019 16:09
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