Cytomegalovirus Cell-Mediated Immunity: Ready for Routine Use?
Details
Serval ID
serval:BIB_A3A4CB6DC8E4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cytomegalovirus Cell-Mediated Immunity: Ready for Routine Use?
Journal
Transplant international
ISSN
1432-2277 (Electronic)
ISSN-L
0934-0874
Publication state
Published
Issued date
2023
Peer-reviewed
Oui
Volume
36
Pages
11963
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Abstract
Utilizing assays that assess specific T-cell-mediated immunity against cytomegalovirus (CMV) holds the potential to enhance personalized strategies aimed at preventing and treating CMV in organ transplantation. This includes improved risk stratification during transplantation compared to relying solely on CMV serostatus, as well as determining the optimal duration of antiviral prophylaxis, deciding on antiviral therapy when asymptomatic replication occurs, and estimating the risk of recurrence. In this review, we initially provide an overlook of the current concepts into the immune control of CMV after transplantation. We then summarize the existent literature on the clinical experience of the use of immune monitoring in organ transplantation, with a particular interest on the outcomes of interventional trials. Current evidence indicates that cell-mediated immune assays are helpful in identifying patients at low risk for replication for whom preventive measures against CMV can be safely withheld. As more data accumulates from these and other clinical scenarios, it is foreseeable that these assays will likely become part of the routine clinical practice in organ transplantation.
Keywords
Humans, Cytomegalovirus, Cytomegalovirus Infections/drug therapy, Antiviral Agents/therapeutic use, Immunity, Cellular, Organ Transplantation, antiviral prophylaxis, cytomegalovirus management, immune monitoring, innate immunity, preventive strategies
Pubmed
Web of science
Open Access
Yes
Create date
01/12/2023 10:39
Last modification date
08/08/2024 7:38