Daytime sleepiness with and without cataplexy in Chinese-Taiwanese patients.

Details

Serval ID
serval:BIB_A384863FAB40
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Daytime sleepiness with and without cataplexy in Chinese-Taiwanese patients.
Journal
Sleep Medicine
Author(s)
Huang Y.S., Tafti M., Guilleminault C.
ISSN
1389-9457[print], 1389-9457[linking]
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
7
Number
5
Pages
454-457
Language
english
Abstract
BACKGROUND AND PURPOSE: Investigation of Chinese-Taiwanese patients with excessive sleepiness, but no association with other sleep disorders, and with the presence or absence of cataplexy. PATIENTS AND METHODS: Thirty-five patients, successively referred between 2002 and 2004, underwent polysomnography (PSG), repeat multiple sleep latency test (MSLT), and human leukocyte antigen (HLA) typing. Three patients without cataplexy also had cerebrospinal fluid (CSF) hypocretin measurements. RESULTS: DQB1*0602 was associated with cataplexy in over 90% of Chinese-Taiwanese cases. Absence of cataplexy and <2 sleep-onset REM periods (SOREMPs) was seen in only two subjects, but presence of two SOREMPs did not dissociate DQB1*0602 positive and negative or cataplexy positive and negative subjects. As a group, narcoleptics with cataplexy had a higher number of SOREMPs, and the mean sleep latency was much shorter in narcoleptics with cataplexy than in the non-cataplectic patients, independent of the number of SOREMPs. CONCLUSIONS: Chinese-Taiwanese patients with cataplexy present with similar HLA findings as Black and Caucasian patients, but the presence of two or more SOREMPs in Chinese-Taiwanese patients is not a sufficient diagnostic tool to identify narcolepsy. When cataplexy is not present, description of PSG nd HLA findings may be a better approach than using a label with little scientific significance, allowing for better collection of patients' phenotype.
Keywords
Adolescent, Adult, Asian Continental Ancestry Group/genetics, Biological Markers/blood, Biological Markers/cerebrospinal fluid, Cataplexy/ethnology, Cataplexy/physiopathology, Female, HLA-DQ Antigens/blood, Histocompatibility Testing, Humans, Intracellular Signaling Peptides and Proteins/cerebrospinal fluid, Male, Membrane Glycoproteins/blood, Narcolepsy/diagnosis, Narcolepsy/ethnology, Neuropeptides/cerebrospinal fluid, Phenotype, Polysomnography, Sleep, REM, Taiwan/epidemiology
Pubmed
Web of science
Create date
24/01/2008 15:55
Last modification date
20/08/2019 15:09
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