Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment

Details

Serval ID
serval:BIB_A36A1B008226
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment
Journal
Journal of Pediatrics
Author(s)
Hohlfeld  P., Daffos  F., Thulliez  P., Aufrant  C., Couvreur  J., MacAleese  J., Descombey  D., Forestier  F.
ISSN
0022-3476 (Print)
Publication state
Published
Issued date
11/1989
Volume
115
Number
5 Pt 1
Pages
765-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
Eight-nine cases of fetal Toxoplasma infection are reported in women treated with spiramycin during pregnancy. Thirty-four pregnancy terminations were performed (2.7% of the total number of acquired Toxoplasma infections during pregnancy). Fifty-two pregnancies were allowed to proceed (43 being additionally treated with pyrimethamine and sulfonamides), leading to the birth of 54 live infants. After a mean follow-up period of 19 months, 41 infants had evidence of subclinical Toxoplasma infection, 12 had a benign form, and one had severe congenital toxoplasmosis (this infant did not receive the additional treatment during pregnancy). Efficacy of the additional treatment with pyrimethamine and sulfonamides was demonstrated by a significant reduction of severe congenital toxoplasmosis and the relative decrease of the ratio of benign to subclinical forms. We recommended that spiramycin treatment be started as soon as possible once the diagnosis of maternal Toxoplasma infection during pregnancy is proved or strongly suspected, because a prolonged time interval between onset of infection and start of treatment seems to be associated with the presence of severe fetal lesions at the time of prenatal diagnosis.
Keywords
Female Follow-Up Studies Humans Infant, Newborn Predictive Value of Tests Pregnancy Pregnancy Complications, Infectious/*drug therapy *Pregnancy Outcome Prenatal Diagnosis Prognosis Pyrimethamine/therapeutic use Spiramycin/therapeutic use Sulfonamides/therapeutic use Toxoplasmosis/*drug therapy Toxoplasmosis, Congenital/*diagnosis/drug therapy/etiology Ultrasonography
Pubmed
Web of science
Create date
25/01/2008 11:11
Last modification date
20/08/2019 15:09
Usage data