In-vitro-Aktivitat von Cefuroxim-Axetil gegen Erreger bakterieller Infektionen des Respirationstrakts. [In-vitro activity of cefuroxime-axetil against pathogens of bacterial infections of the respiratory tract]

Details

Serval ID
serval:BIB_A2F0A7C629A6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In-vitro-Aktivitat von Cefuroxim-Axetil gegen Erreger bakterieller Infektionen des Respirationstrakts. [In-vitro activity of cefuroxime-axetil against pathogens of bacterial infections of the respiratory tract]
Journal
Schweizerische Rundschau fur Medizin Praxis
Author(s)
Kayser  F. H., Bille  J.
ISSN
1013-2058
Publication state
Published
Issued date
11/1990
Volume
79
Number
45
Pages
1383-6
Notes
Comparative Study
English Abstract
Journal Article --- Old month value: Nov 6
Abstract
Cefuroxime-Axetil is an ester of cefuroxime, which can be used as an oral antimicrobial agent. The prodrug is hydrolysed by esterases of the gut mucosa, setting free the active cefuroxime. This second generation cephalosporin is well known since more than a decade as a cephalosporin possessing high stability against gram positive and gram negative beta-lactamases. Due to its pharmacokinetic properties and its wide spectrum of activity, cefuroxime-axetil was recommended to be used as an oral agent in bacterial infections of the respiratory tract. This paper describes the in vitro activity of cefuroxime against respiratory tract pathogens and compares it with that of ampicillin and amoxicillin, amoxicillin/clavulanic acid, cefaclor, chloramphenicol, tetracycline, erythromycin and trimethoprim/sulphamethoxazole. Cefuroxime had good activity against beta-lactamase-producing and beta-lactamase-negative H. influenzae and M. catarrhalis. As expected, the aminopenicillins showed reduced activity against beta-lactamase-producing strains of these organisms. Amoxicillin/clavulanic acid and, to a lesser degree, cefaclor also showed good activity against these bacteria. Cefuroxime was highly active against penicillin-susceptible pneumococci, but showed impaired activity against penicillin-resistant strains. Therefore, this drug should not be used in infections caused by penicillin-resistant pneumococci. Resistance to penicillin in pneumococci isolated in Switzerland is not a problem at the present time. For many years, such strains were isolated only sporadically. Cefuroxime showed also a high in vitro activity against streptococci of serogroups A, B, C and G, which are encountered as respiratory tract pathogens. Against beta-lactamase-positive and -negative staphylococci, cefuroxime showed good activity. The drug was inactive, however, against methicillin-resistant strains.
Keywords
Anti-Bacterial Agents/pharmacology Bacteria/*drug effects/enzymology Cefuroxime/*analogs & derivatives/pharmacokinetics/pharmacology Humans Penicillin Resistance *Prodrugs Respiratory System/*microbiology beta-Lactamases/metabolism
Pubmed
Create date
11/02/2008 12:40
Last modification date
20/08/2019 15:08
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