Spectrin and related molecules.

Details

Serval ID
serval:BIB_A2DC44039551
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Spectrin and related molecules.
Journal
CRC Critical Reviews In Biochemistry
Author(s)
Goodman S.R., Krebs K.E., Whitfield C.F., Riederer B.M., Zagon I.S.
ISSN
0045-6411 (Print)
ISSN-L
0045-6411
Publication state
Published
Issued date
1988
Volume
23
Number
2
Pages
171-234
Language
english
Abstract
This review begins with a complete discussion of the erythrocyte spectrin membrane skeleton. Particular attention is given to our current knowledge of the structure of the RBC spectrin molecule, its synthesis, assembly, and turnover, and its interactions with spectrin-binding proteins (ankyrin, protein 4.1, and actin). We then give a historical account of the discovery of nonerythroid spectrin. Since the chicken intestinal form of spectrin (TW260/240) and the brain form of spectrin (fodrin) are the best characterized of the nonerythroid spectrins, we compare these molecules to RBC spectrin. Studies establishing the existence of two brain spectrin isoforms are discussed, including a description of the location of these spectrin isoforms at the light- and electron-microscope level of resolution; a comparison of their structure and interactions with spectrin-binding proteins (ankyrin, actin, synapsin I, amelin, and calmodulin); a description of their expression during brain development; and hypotheses concerning their potential roles in axonal transport and synaptic transmission.
Keywords
Animals, Humans, Spectrin/physiology
Pubmed
Web of science
Create date
24/01/2008 14:35
Last modification date
20/08/2019 15:08
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