Horizontal partial laryngectomy for supraglottic squamous cell carcinoma

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Serval ID
serval:BIB_A2B0993C99AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Horizontal partial laryngectomy for supraglottic squamous cell carcinoma
Journal
European Archives of Oto-Rhino-Laryngology
Author(s)
Bron  L. P., Soldati  D., Monod  M. L., Megevand  C., Brossard  E., Monnier  P., Pasche  P.
ISSN
0937-4477 (Print)
Publication state
Published
Issued date
04/2005
Volume
262
Number
4
Pages
302-6
Notes
Journal Article --- Old month value: Apr
Abstract
Between 1981-1999, 75 patients treated for supraglottic SCC with horizontal supraglottic laryngectomy (HSL) at the Otolaryngology Head and Neck Surgery Department of Lausanne University Hospital were retrospectively studied. There were 16 patients with T1, 46 with T2 and 13 with T3 tumors. Among these, 16 patients (21%) had clinical neck disease corresponding to stage I, II, III and IV in 12, 39, 18 and 6 patients, respectively. All patients had HSL. Most patients had either elective or therapeutic bilateral level II-IV selective neck dissection. Six patients (8%) with advanced neck disease had ipsilateral radical and controlateral elective II-IV selective neck dissections. Adjuvant radiotherapy was given to 25 patients (30%) for either positive surgical margins (n=8), pathological nodal status (n=14) or both (n=3). Median follow-up was 48 months (range, 24-199). Five-year disease-specific survival and locoregional and local control were 92, 90 and 92.5%, respectively. Among five patients who were diagnosed with local recurrence, one had a total laryngectomy (1.4%); the others were treated by endoscopic laser surgery. Two patients had both a local and regional recurrence. They were salvaged with combined surgery and radiotherapy, but eventually died of their disease. Cartilage infiltration seems to influence both local control (P=0.03) and disease-specific survival (P=0.06). There was a trend for worse survival with pathological node involvement (P=0.15) and extralaryngeal extension of the cancer (P=0.1). All patients except one recovered a close to normal function after the treatment. Aspiration was present in 16 patients (26%) in the early postoperative period. A median of 16 days (7-9) was necessary to recover a close to normal diet. Decannulation took a median of 17 days (8-93). Seven patients kept a tracheotomy tube for up to 3 months because of persistent aspiration. There was no permanent tracheostomy or total laryngectomy for functional purposes. Horizontal supraglottic laryngectomy remains an adequate therapeutic alternative for supraglottic squamous cell carcinoma, offering an excellent oncological outcome. The postoperative functional morbidity is substantial, indicating the need for careful patient selection, but good laryngeal function recovery is the rule. The surgical alternative is endoscopic laser surgery, which may offer comparable oncological results with less functional morbidity. Nevertheless, these two different techniques need to be compared prospectively.
Keywords
Adult Aged Carcinoma, Squamous Cell/mortality/pathology/*surgery Disease-Free Survival Female Follow-Up Studies Glottis/pathology/*surgery Humans Laryngeal Neoplasms/mortality/pathology/*surgery Laryngectomy/adverse effects/*methods Larynx/pathology/physiopathology/surgery Male Middle Aged Recovery of Function/physiology Retrospective Studies Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:47
Last modification date
01/10/2019 6:19
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