Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.

Details

Ressource 1Download: 25721933_BIB_A2AA8A79D1EB.pdf (3941.89 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_A2AA8A79D1EB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.
Journal
Nature Communications
Author(s)
Parkash J., Messina A., Langlet F., Cimino I., Loyens A., Mazur D., Gallet S., Balland E., Malone S.A., Pralong F., Cagnoni G., Schellino R., De Marchis S., Mazzone M., Pasterkamp R.J., Tamagnone L., Prevot V., Giacobini P.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
6
Pages
6385
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic-pituitary-gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle.
Pubmed
Web of science
Open Access
Yes
Create date
02/04/2015 20:32
Last modification date
30/04/2021 7:13
Usage data