Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex.

Details

Serval ID
serval:BIB_A28DE3A099F1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex.
Journal
Psychopharmacology
Author(s)
Rigucci S., Xin L., Klauser P., Baumann P.S., Alameda L., Cleusix M., Jenni R., Ferrari C., Pompili M., Gruetter R., Do K.Q., Conus P.
ISSN
1432-2072 (Electronic)
ISSN-L
0033-3158
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
235
Number
1
Pages
13-22
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Recent studies have shown that cannabis may disrupt glutamate (Glu) signaling depressing Glu tone in frequent users. Current evidence have also consistently reported lower Glu-levels in various brain regions, particularly in the medial prefrontal cortex (mPFC) of chronic schizophrenia patients, while findings in early psychosis (EP) are not conclusive. Since cannabis may alter Glu synaptic plasticity and its use is a known risk factor for psychosis, studies focusing on Glu signaling in EP with or without a concomitant cannabis-usage seem crucial.
We investigate the effect of cannabis use on prefrontal Glu-levels in EP users vs. both EP non-users and healthy controls (HC).
Magnetic resonance spectroscopy was used to measure [Glu <sub>mPFC</sub> ] of 35 EP subjects (18 of whom were cannabis users) and 33 HC. For correlative analysis, neuropsychological performances were scored by the MATRICS-consensus cognitive battery.
[Glu <sub>mPFC</sub> ] was lower in EP users comparing to both HC and EP non-users (p < 0.001 and p = 0.01, respectively), while no differences were observed between EP non-users and HC. A greater [Glu <sub>mPFC</sub> ]-decline with age was observed in EP users (r = -.46; p = 0.04), but not in EP non-users or HC. Among neuropsychological outcomes, working memory was the only domain that differentiates patients depending on their cannabis use, with users having poorer performances.
Cannabis use is associated with reduced prefrontal [Glu <sub>mPFC</sub> ] and with a stronger Glu-levels decline with age. Glutamatergic abnormalities might influence the cognitive impairment observed in users and have some relevance for the progression of the disease.
Keywords
Adolescent, Adult, Diagnostic and Statistical Manual of Mental Disorders, Female, Glutamic Acid/metabolism, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Marijuana Abuse/complications, Marijuana Abuse/metabolism, Marijuana Abuse/psychology, Memory, Short-Term, Neuropsychological Tests, Prefrontal Cortex/diagnostic imaging, Prefrontal Cortex/metabolism, Psychomotor Performance/drug effects, Psychoses, Substance-Induced/diagnostic imaging, Psychoses, Substance-Induced/metabolism, Psychoses, Substance-Induced/psychology, Signal Transduction/drug effects, Socioeconomic Factors, Young Adult, Cannabis, Cognition, Early psychosis, Glutamate, Magnetic resonance spectroscopy
Pubmed
Web of science
Create date
31/10/2017 11:22
Last modification date
20/08/2019 16:08
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