From T cell “exhaustion” to anti-cancer immunity

Details

Serval ID
serval:BIB_A25E5BACDB1A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
From T cell “exhaustion” to anti-cancer immunity
Journal
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Author(s)
Verdeil Grégory, Fuertes Marraco Silvia A., Murray Timothy, Speiser Daniel E.
ISSN
0304-419X
ISSN-L
1879-2561
Publication state
Published
Issued date
01/2016
Peer-reviewed
Oui
Volume
1865
Number
1
Pages
49-57
Language
english
Abstract
The immune system has the potential to protect from malignant diseases for extended periods of time. Unfortunately, spontaneous immune responses are often inefficient. Significant effort is required to develop reliable, broadly applicable immunotherapies for cancer patients. A major innovation was transplantation with hematopoietic stem cells from genetically distinct donors for patients with hematologic malignancies. In this setting, donor T cells induce long-term remission by keeping cancer cells in check through powerful allogeneic graft-versus-leukemia effects. More recently, a long awaited breakthrough for patients with solid tissue cancers was achieved, by means of therapeutic blockade of T cell inhibitory receptors. In untreated cancer patients, T cells are dysfunctional and remain in a state of T cell "exhaustion". Nonetheless, they often retain a high potential for successful defense against cancer, indicating that many T cells are not entirely and irreversibly exhausted but can be mobilized to become highly functional. Novel antibody therapies that block inhibitory receptors can lead to strong activation of anti-tumor T cells, mediating clinically significant anti-cancer immunity for many years. Here we review these new treatments and the current knowledge on tumor antigen-specific T cells.
Keywords
Genetics, Cancer Research, Oncology
Pubmed
Web of science
Create date
29/03/2016 17:25
Last modification date
20/08/2019 15:08
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