Metabolic syndrome is associated with colorectal cancer in men.

Details

Serval ID
serval:BIB_A22BC27A844D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic syndrome is associated with colorectal cancer in men.
Journal
European Journal of Cancer
Author(s)
Pelucchi Claudio, Negri Eva, Talamini Renato, Levi Fabio, Giacosa Attilio, Crispo Anna, Bidoli Ettore, Montella Maurizio, Franceschi Silvia, La Vecchia Carlo
ISSN
1879-0852[electronic], 0959-8049[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
46
Number
10
Pages
1866-1872
Language
english
Abstract
AIM OF THE STUDY: We assessed the relation between metabolic syndrome (MetS) and its components and colorectal cancer. METHODS: We analysed data from a multicentre case-control study conducted in Italy and Switzerland, including 1378 cases of colon cancer, 878 cases of rectal cancer and 4661 controls. All cases were incident and histologically confirmed. Controls were subjects admitted to the same hospitals as cases with acute non-malignant conditions. MetS was defined according to the International Diabetes Federation criteria. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated by multiple logistic regression models, including terms for major identified confounding factors for colorectal cancer. RESULTS: With reference to each component of the MetS, the ORs of colorectal cancer in men were 1.27 (95% CI, 0.95-1.69) for diabetes, 1.24 (95% CI, 1.03-1.48) for hypertension, 1.14 (95% CI, 0.93-1.40) for hypercholesterolaemia and 1.26 (95% CI, 1.08-1.48) for overweight at age 30. The corresponding ORs in women were 1.20 (95% CI, 0.82-1.75), 0.87 (95% CI, 0.71-1.06), 0.83 (95% CI, 0.66-1.03) and 1.06 (95% CI, 0.86-1.30). Colorectal cancer risk was increased in men (OR=1.86; 95% CI, 1.21-2.86), but not in women (OR=1.13; 95% CI, 0.66-1.93), with MetS. The ORs were 2.09 (95% CI, 1.38-3.18) in men and 1.15 (95% CI, 0.68-1.94) in women with > or =3 components of the MetS, as compared to no component. Results were similar for colon and rectal cancers. CONCLUSION: This study supports a direct association between MetS and both colon and rectal cancers in men, but not in women.
Keywords
Adult, Aged, Case-Control Studies, Colonic Neoplasms/etiology, Female, Humans, Male, Metabolic Syndrome X/complications, Middle Aged, Rectal Neoplasms/etiology, Risk Factors
Pubmed
Web of science
Create date
21/10/2010 12:53
Last modification date
20/08/2019 15:08
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