Role of the ubiquitin system in regulating ion transport.

Details

Ressource 1Download: serval:BIB_A1D428672041.P001 (569.93 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_A1D428672041
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Role of the ubiquitin system in regulating ion transport.
Journal
Pflügers Archiv
Author(s)
Rotin D., Staub O.
ISSN
1432-2013 (Electronic)
ISSN-L
0031-6768
Publication state
Published
Issued date
2011
Volume
461
Number
1
Pages
1-21
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
Ion channels and transporters play a critical role in ion and fluid homeostasis and thus in normal animal physiology and pathology. Tight regulation of these transmembrane proteins is therefore essential. In recent years, many studies have focused their attention on the role of the ubiquitin system in regulating ion channels and transporters, initialed by the discoveries of the role of this system in processing of Cystic Fibrosis Transmembrane Regulator (CFTR), and in regulating endocytosis of the epithelial Na(+) channel (ENaC) by the Nedd4 family of ubiquitin ligases (mainly Nedd4-2). In this review, we discuss the role of the ubiquitin system in ER Associated Degradation (ERAD) of ion channels, and in the regulation of endocytosis and lysosomal sorting of ion channels and transporters, focusing primarily in mammalian cells. We also briefly discuss the role of ubiquitin like molecules (such as SUMO) in such regulation, for which much less is known so far.
Pubmed
Web of science
Open Access
Yes
Create date
20/03/2011 20:49
Last modification date
20/10/2020 11:12
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