Simultaneous conventional photorefractive keratectomy and corneal collagen cross-linking for pellucid marginal corneal degeneration.

Details

Serval ID
serval:BIB_A1B7FDF6E59C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Simultaneous conventional photorefractive keratectomy and corneal collagen cross-linking for pellucid marginal corneal degeneration.
Journal
Journal of refractive surgery
Author(s)
Kymionis G.D., Grentzelos M.A., Plaka A.D., Tsoulnaras K.I., Kankariya V.P., Shehadeh M.M., Pallikaris I.G.
ISSN
1081-597X (Print)
ISSN-L
1081-597X
Publication state
Published
Issued date
04/2014
Peer-reviewed
Oui
Volume
30
Number
4
Pages
272-276
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To present the results after simultaneous conventional photorefractive keratectomy combined with corneal collagen cross-linking for pellucid marginal corneal degeneration.
In this prospective, interventional case series, 6 patients (8 eyes) with pellucid marginal corneal degeneration were enrolled. All patients underwent simultaneous conventional photorefractive keratectomy combined with corneal collagen cross-linking; corneal epithelium was removed by transepithelial phototherapeutic keratectomy during treatment (Cretan protocol plus conventional photorefractive keratectomy). Visual and refractive outcomes were evaluated along with endothelial cell density preoperatively and at 1, 3, 6, and 12 months postoperatively.
No intraoperative or postoperative complications were observed in any of the patients. LogMAR mean uncorrected distance visual acuity improved significantly from 1.05 ± 0.33 preoperatively to 0.41 ± 0.27 (P = .018) at 12 months postoperatively. Mean corrected distance visual acuity did not change significantly (P > .05) postoperatively. Mean spherical equivalent improved significantly from -3.52 ± 2.29 diopters preoperatively to -1.57 ± 1.76 diopters (P = .028) at last follow-up. Mean corneal astigmatism was significantly reduced from -6.83 ± 2.33 diopters preoperatively to -4.71 ± 1.89 diopters (P = .018) at the last follow-up. No endothelial cell density alterations were observed throughout the follow-up period (P > .05).
Simultaneous conventional photorefractive keratectomy combined with corneal collagen cross-linking seems to be an effective, safe, and promising treatment for the management of pellucid marginal corneal degeneration.
Keywords
Adult, Cell Count, Collagen/metabolism, Combined Modality Therapy, Corneal Dystrophies, Hereditary/drug therapy, Corneal Dystrophies, Hereditary/surgery, Corneal Dystrophies, Hereditary/therapy, Corneal Stroma/metabolism, Corneal Topography, Cross-Linking Reagents/therapeutic use, Endothelium, Corneal/pathology, Female, Follow-Up Studies, Humans, Lasers, Excimer/therapeutic use, Male, Middle Aged, Photorefractive Keratectomy/methods, Photosensitizing Agents/therapeutic use, Refraction, Ocular/physiology, Riboflavin/therapeutic use, Treatment Outcome, Ultraviolet Rays, Visual Acuity/physiology
Pubmed
Web of science
Create date
01/10/2019 12:46
Last modification date
06/10/2019 5:26
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