Tumor Resident Memory T Cells: New Players in Immune Surveillance and Therapy.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_A1AD953828BB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tumor Resident Memory T Cells: New Players in Immune Surveillance and Therapy.
Journal
Frontiers in immunology
Author(s)
Dumauthioz N., Labiano S., Romero P.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
9
Pages
2076
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
Tissue resident memory T cells (Trm) are a subset of memory T cells mainly described in inflammation and infection settings. Their location in peripheral tissues, such as lungs, gut, or skin, makes them the earliest T cell population to respond upon antigen recognition or under inflammatory conditions. The study of Trm cells in the field of cancer, and particularly in cancer immunotherapy, has recently gained considerable momentum. Different reports have shown that the vaccination route is critical to promote Trm generation in preclinical cancer models. Cancer vaccines administered directly at the mucosa, frequently result in enhanced Trm formation in mucosal cancers compared to vaccinations via intramuscular or subcutaneous routes. Moreover, the intratumoral presence of T cells expressing the integrin CD103 has been reported to strongly correlate with a favorable prognosis for cancer patients. In spite of recent progress, the full spectrum of Trm anti-tumoral functions still needs to be fully established, particularly in cancer patients, in different clinical contexts. In this mini-review we focus on the recent vaccination strategies aimed at generating Trm cells, as well as evidence supporting their association with patient survival in different cancer types. We believe that collectively, this information provides a strong rationale to target Trm for cancer immunotherapy.
Keywords
Animals, Antigens, CD/immunology, Cancer Vaccines/immunology, Humans, Immunologic Memory, Immunologic Surveillance, Integrin alpha Chains/immunology, Neoplasms/immunology, Neoplasms/pathology, Neoplasms/therapy, T-Lymphocytes/immunology, T-Lymphocytes/pathology, Vaccination, CD103, cancer prognosis, immunotherapy, mucosal route, tissue resident memory, vaccination
Pubmed
Web of science
Open Access
Yes
Create date
05/10/2018 17:35
Last modification date
28/09/2019 6:08
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