Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer.

Details

Serval ID
serval:BIB_A19532FDD59E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer.
Journal
Vaccines
Author(s)
Saillard M., Cenerenti M., Romero P., Jandus C.
ISSN
2076-393X (Print)
ISSN-L
2076-393X
Publication state
Published
Issued date
04/05/2021
Peer-reviewed
Oui
Volume
9
Number
5
Pages
454
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Immunotherapy has become a standard treatment in many cancers and it is based on three main therapeutic axes: immune checkpoint blockade (ICB), vaccination and adoptive cell transfer (ACT). If originally these therapies mainly focused on exploiting CD8 T cells given their role in the direct elimination of tumor cells, increasing evidence highlights the crucial role CD4 T cells play in the antitumor immune response. Indeed, these cells can profoundly modulate the tumor microenvironment (TME) by secreting different types of cytokine or by directly eliminating cancer cells. In this review, we describe how different CD4 T cell subsets can contribute to tumor immune responses during immunotherapy and the novel high-throughput immune monitoring tools that are expected to facilitate the study of CD4 T cells, at antigen-specific and single cell level, thus accelerating bench-to-bed translational research in cancer.
Keywords
CD4 T cells, antigen-specific, cancer, immune monitoring, immunotherapy
Pubmed
Web of science
Open Access
Yes
Create date
04/06/2021 18:23
Last modification date
18/06/2021 6:37
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