Carotenoid intake and head and neck cancer : a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Details

Serval ID
serval:BIB_A19468F54FDC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Carotenoid intake and head and neck cancer : a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
Journal
European Journal of Epidemiology
Author(s)
Leoncini E., Edefonti V., Hashibe M., Parpinel M., Cadoni G., Ferraroni M., Serraino D., Matsuo K., Olshan A.F., Zevallos J.P., Winn D.M., Moysich K., Zhang Z.F., Morgenstern H., Levi F., Kelsey K., McClean M., Bosetti C., Schantz S., Yu G.P., Boffetta P., Lee Y.C., Chuang S.C., Decarli A., La Vecchia C., Boccia S.
ISSN
1573-7284 (Electronic)
ISSN-L
0393-2990
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
31
Number
4
Pages
124
Language
english
Abstract
Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case-control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29-47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24-50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6-29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0-32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p < 0.05). The odds ratio for the combined effect of low carotenoid intake and high alcohol or tobacco consumption versus high carotenoid intake and low alcohol or tobacco consumption ranged from 7 (95 % CI 5-9) to 33 (95 % CI 23-49). A diet rich in carotenoids may protect against HNC. Persons with both low carotenoid intake and high tobacco or alcohol are at substantially higher risk of HNC.
Pubmed
Web of science
Create date
04/06/2015 7:57
Last modification date
20/08/2019 15:07
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