Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_A14B3C593709
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury.
Journal
Annals of Physical and Rehabilitation Medicine
Author(s)
van den Brand R., Mignardot J.B., von Zitzewitz J., Le Goff C., Fumeaux N., Wagner F., Capogrosso M., Martin Moraud E., Micera S., Schurch B., Curt A., Carda S., Bloch J., Courtine G.
ISSN
1877-0665 (Electronic)
ISSN-L
1877-0657
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
58
Number
4
Pages
232-237
Language
english
Abstract
Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients' autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-based training paradigms restored supraspinal control of locomotion in rodent models of severe spinal cord injury. This treatment promoted extensive and ubiquitous remodeling of spared circuits and residual neural pathways. In four chronic paraplegic individuals, electrical neuromodulation of the spinal cord resulted in the immediate recovery of voluntary leg movements, suggesting that the therapeutic concepts developed in rodent models may also apply to humans. Here, we briefly review previous work, summarize current developments, and highlight impediments to translate these interventions into medical practice to improve functional recovery of spinal-cord-injured individuals.
Pubmed
Open Access
Yes
Create date
12/10/2016 11:48
Last modification date
20/08/2019 16:07
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