Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice.

Details

Serval ID
serval:BIB_A13D68111785
Type
Article: article from journal or magazin.
Collection
Publications
Title
Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice.
Journal
The EMBO journal
Author(s)
Madani R., Hulo S., Toni N., Madani H., Steimer T., Muller D., Vassalli J.D.
ISSN
0261-4189
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
18
Number
11
Pages
3007-3012
Language
english
Notes
Publication types: In Vitro ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Adult cortical neurons can produce tissue-type plasminogen activator (tPA), an extracellular protease that plays a critical role in fibrinolysis and tissue remodelling processes. There is growing evidence that extracellular proteolysis may be involved in synaptic plasticity, axonal remodelling and neurotoxicity in the adult central nervous system. Here we show that transgenic mice overexpressing tPA in post-natal neurons have increased and prolonged hippocampal long-term potentiation (LTP), and improved performance in spatial orientation learning tasks. Extracellular proteolysis catalysed by tPA may facilitate synaptic micro-remodelling, and thereby play a role in activity-dependent neuronal plasticity and learning.
Keywords
Animals, Electrophysiology, Gene Expression, Hippocampus/anatomy & histology, Hippocampus/cytology, Learning, Long-Term Potentiation, Memory, Mice, Mice, Transgenic, Neurons/metabolism, Neurons/physiology, Space Perception, Swimming, Synapses/physiology, Tissue Plasminogen Activator/genetics, Tissue Plasminogen Activator/metabolism, Transgenes/genetics
Pubmed
Web of science
Open Access
Yes
Create date
22/01/2010 8:08
Last modification date
20/08/2019 15:07
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