Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?

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Serval ID
serval:BIB_A1139DF4360F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?
Journal
Virchows Archiv
Author(s)
Sandmeier  D., Seelentag  W., Bouzourene  H.
ISSN
0945-6317 (Print)
Publication state
Published
Issued date
2007
Volume
450
Number
6
Pages
613-618
Notes
PT - Journal Article
Abstract
The distinction between serrated polyps of the colon is complex, particularly between hyperplastic polyps (HP) and sessile serrated adenomas (SSA). Recent data show that SSA might be the precursors of serrated colonic cancers, underlining the necessity of identifying them. We characterized the demographic and pathologic characteristics of 102 serrated lesions among 321 polyps of the colorectum and determined if SSA can be microscopically distinguished from HP in biopsy material of a daily practice. There were 81 HP (79%) and 7 SSA (7%) of which one displayed low-grade dysplasia. Only six serrated polyps (6%) could not be correctly classified. The main architectural criteria for distinguishing SSA from HP is the serrated feature along the crypt axis and the rarity of undifferentiated cells in the lower third of the crypts. SSA was significantly more often located in the right colon and larger (median, 11 vs 4 mm) than HP. SSA are rare serrated polyps that can be distinguished from HP based on their morphology, location in the right colon, and larger size. One SSA of our series showed low-grade dysplasia supporting the concept that this lesion might be a precursor of serrated adenocarcinoma
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 19:33
Last modification date
25/09/2019 7:10
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