Validation of the DRAGON Score in 12 Stroke Centers in Anterior and Posterior Circulation.

Details

Serval ID
serval:BIB_A0DCEF8D2374
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Validation of the DRAGON Score in 12 Stroke Centers in Anterior and Posterior Circulation.
Journal
Stroke
Author(s)
Strbian D., Seiffge D.J., Breuer L., Numminen H., Michel P., Meretoja A., Coote S., Bordet R., Obach V., Weder B., Jung S., Caso V., Curtze S., Ollikainen J., Lyrer P.A., Eskandari A., Mattle H.P., Chamorro A., Leys D., Bladin C., Davis S.M., Köhrmann M., Engelter S.T., Tatlisumak T.
ISSN
1524-4628 (Electronic)
ISSN-L
0039-2499
Publication state
Published
Issued date
2013
Volume
44
Number
10
Pages
2718-2721
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
BACKGROUND AND PURPOSE: The DRAGON score predicts functional outcome in the hyperacute phase of intravenous thrombolysis treatment of ischemic stroke patients. We aimed to validate the score in a large multicenter cohort in anterior and posterior circulation.
METHODS: Prospectively collected data of consecutive ischemic stroke patients who received intravenous thrombolysis in 12 stroke centers were merged (n=5471). We excluded patients lacking data necessary to calculate the score and patients with missing 3-month modified Rankin scale scores. The final cohort comprised 4519 eligible patients. We assessed the performance of the DRAGON score with area under the receiver operating characteristic curve in the whole cohort for both good (modified Rankin scale score, 0-2) and miserable (modified Rankin scale score, 5-6) outcomes.
RESULTS: Area under the receiver operating characteristic curve was 0.84 (0.82-0.85) for miserable outcome and 0.82 (0.80-0.83) for good outcome. Proportions of patients with good outcome were 96%, 93%, 78%, and 0% for 0 to 1, 2, 3, and 8 to 10 score points, respectively. Proportions of patients with miserable outcome were 0%, 2%, 4%, 89%, and 97% for 0 to 1, 2, 3, 8, and 9 to 10 points, respectively. When tested separately for anterior and posterior circulation, there was no difference in performance (P=0.55); areas under the receiver operating characteristic curve were 0.84 (0.83-0.86) and 0.82 (0.78-0.87), respectively. No sex-related difference in performance was observed (P=0.25).
CONCLUSIONS: The DRAGON score showed very good performance in the large merged cohort in both anterior and posterior circulation strokes. The DRAGON score provides rapid estimation of patient prognosis and supports clinical decision-making in the hyperacute phase of stroke care (eg, when invasive add-on strategies are considered).
Pubmed
Web of science
Open Access
Yes
Create date
01/11/2013 20:52
Last modification date
20/08/2019 15:06
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